ENSMUSG00000008763


Mus musculus

Features
Gene ID: ENSMUSG00000008763
  
Biological name :Man1a2
  
Synonyms : Man1a2 / Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB / P39098
  
Possible biological names infered from orthology : mannosidase alpha class 1A member 2 / O60476
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 100562208
Gene end: 100685503
  
Corresponding Affymetrix probe sets: 10500614 (MoGene1.0st)   1420976_at (Mouse Genome 430 2.0 Array)   1420977_at (Mouse Genome 430 2.0 Array)   1434395_at (Mouse Genome 430 2.0 Array)   1456534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008907
Ensembl peptide - ENSMUSP00000143695
Ensembl peptide - ENSMUSP00000116489
NCBI entrez gene - 17156     See in Manteia.
MGI - MGI:104676
RefSeq - NM_010763
RefSeq Peptide - NP_034893
swissprot - A2A723
swissprot - A0A0G2JGT9
swissprot - P39098
Ensembl - ENSMUSG00000008763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 man1a2ENSDARG00000041728Danio rerio
 ENSGALG00000041564Gallus gallus
 ENSGALG00000014361Gallus gallus
 MAN1A2ENSG00000198162Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Man1a / P45700 / mannosidase 1, alpha / P33908* / MAN1A1* / mannosidase alpha class 1A member 1*ENSMUSG0000000374663
Man1c1 / mannosidase alpha class 1C member 1 / Q9NR34*ENSMUSG0000003730649
A2AJ15 / Man1b1 / Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase / Q9UKM7* / mannosidase alpha class 1B member 1*ENSMUSG0000003664631


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009100 glycoprotein metabolic process IMP
 biological_processGO:0048286 lung alveolus development IMP
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Intra-Golgi traffic
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Bdnftm1Gdy/Bdnf+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Man1a2tm1.1Ahe/Man1a2tm1.1Ahe
Genetic Background: either: 129S4/SvJae-Man1a2tm1.1Ahe or (involves: 129S4/SvJae * C57BL/6 * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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