ENSG00000112053


Homo sapiens

Features
Gene ID: ENSG00000112053
  
Biological name :SLC26A8
  
Synonyms : Q96RN1 / SLC26A8 / solute carrier family 26 member 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.31
Gene start: 35943514
Gene end: 36024868
  
Corresponding Affymetrix probe sets: 237340_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418107
Ensembl peptide - ENSP00000417638
Ensembl peptide - ENSP00000419700
Ensembl peptide - ENSP00000420488
Ensembl peptide - ENSP00000347778
Ensembl peptide - ENSP00000378100
NCBI entrez gene - 116369     See in Manteia.
OMIM - 608480
RefSeq - XM_017010235
RefSeq - NM_001193476
RefSeq - NM_052961
RefSeq - NM_138718
RefSeq - XM_011514294
RefSeq Peptide - NP_443193
RefSeq Peptide - NP_001180405
RefSeq Peptide - NP_619732
swissprot - H7C4T4
swissprot - H7C5E6
swissprot - C9JMV8
swissprot - A0A024RCV0
swissprot - Q96RN1
Ensembl - ENSG00000112053
  
Related genetic diseases (OMIM): 606766 - Spermatogenic failure 3, 606766
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC26A8ENSGALG00000040498Gallus gallus
 Q8R0C3ENSMUSG00000036196Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BXS9 / SLC26A6 / solute carrier family 26 member 6ENSG0000022569723
P40879 / SLC26A3 / solute carrier family 26 member 3ENSG0000009113823
Q7LBE3 / SLC26A9 / solute carrier family 26 member 9ENSG0000017450222
O43511 / SLC26A4 / solute carrier family 26 member 4ENSG0000009113722
P58743 / SLC26A5 / solute carrier family 26 member 5ENSG0000017061521
P50443 / SLC26A2 / solute carrier family 26 member 2ENSG0000015585017
Q9H2B4 / SLC26A1 / solute carrier family 26 member 1ENSG0000014521717
Q8TE54 / SLC26A7 / solute carrier family 26 member 7ENSG0000014760616
Q8NG04 / SLC26A10 / solute carrier family 26 member 10ENSG0000013550215


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR030303  Solute carrier family 26 member 8 (testis anion transporter 1)
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006820 anion transport IEA
 biological_processGO:0006821 chloride transport IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008272 sulfate transport IEA
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0019532 oxalate transport IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030317 flagellated sperm motility IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0048240 sperm capacitation IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005254 chloride channel activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0008509 anion transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IEA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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