ENSG00000170615


Homo sapiens

Features
Gene ID: ENSG00000170615
  
Biological name :SLC26A5
  
Synonyms : P58743 / SLC26A5 / solute carrier family 26 member 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.1
Gene start: 103352730
Gene end: 103446177
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000396833
Ensembl peptide - ENSP00000395568
Ensembl peptide - ENSP00000416502
Ensembl peptide - ENSP00000304783
Ensembl peptide - ENSP00000342396
Ensembl peptide - ENSP00000346325
Ensembl peptide - ENSP00000349210
Ensembl peptide - ENSP00000377324
Ensembl peptide - ENSP00000377328
Ensembl peptide - ENSP00000377330
Ensembl peptide - ENSP00000377331
Ensembl peptide - ENSP00000377336
Ensembl peptide - ENSP00000389018
Ensembl peptide - ENSP00000389733
NCBI entrez gene - 375611     See in Manteia.
OMIM - 604943
RefSeq - XM_011516170
RefSeq - NM_001167962
RefSeq - NM_001321787
RefSeq - NM_198999
RefSeq - NM_206883
RefSeq - NM_206884
RefSeq - NM_206885
RefSeq Peptide - NP_001161434
RefSeq Peptide - NP_001308716
RefSeq Peptide - NP_996768
RefSeq Peptide - NP_945350
RefSeq Peptide - NP_996766
RefSeq Peptide - NP_996767
swissprot - Q7Z7F4
swissprot - Q496J3
swissprot - E9PCM2
swissprot - F8WD50
swissprot - F8WDL4
swissprot - P58743
swissprot - Q496J0
Ensembl - ENSG00000170615
  
Related genetic diseases (OMIM): 613865 - ?Deafness, autosomal recessive 61, 613865
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc26a5ENSDARG00000022424Danio rerio
 SLC26A5ENSGALG00000008222Gallus gallus
 Q99NH7ENSMUSG00000029015Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BXS9 / SLC26A6 / solute carrier family 26 member 6ENSG0000022569739
P40879 / SLC26A3 / solute carrier family 26 member 3ENSG0000009113838
O43511 / SLC26A4 / solute carrier family 26 member 4ENSG0000009113737
Q7LBE3 / SLC26A9 / solute carrier family 26 member 9ENSG0000017450234
P50443 / SLC26A2 / solute carrier family 26 member 2ENSG0000015585033
Q9H2B4 / SLC26A1 / solute carrier family 26 member 1ENSG0000014521730
Q96RN1 / SLC26A8 / solute carrier family 26 member 8ENSG0000011205328
Q8NG04 / SLC26A10 / solute carrier family 26 member 10ENSG0000013550225
Q8TE54 / SLC26A7 / solute carrier family 26 member 7ENSG0000014760625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR018045  Sulphate anion transporter, conserved site
 IPR030282  Prestin
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008272 sulfate transport IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009751 response to salicylic acid IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0015755 fructose transmembrane transport IEA
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034766 negative regulation of ion transmembrane transport IEA
 biological_processGO:0035864 response to potassium ion IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902074 response to salt IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IBA
 biological_processGO:2000147 positive regulation of cell motility IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IBA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IBA
 molecular_functionGO:0030507 spectrin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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