ENSMUSG00000029015


Mus musculus

Features
Gene ID: ENSMUSG00000029015
  
Biological name :Slc26a5
  
Synonyms : Prestin / Q99NH7 / Slc26a5
  
Possible biological names infered from orthology : P58743 / solute carrier family 26 member 5
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 21810655
Gene end: 21865604
  
Corresponding Affymetrix probe sets: 10528360 (MoGene1.0st)   1421725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118263
Ensembl peptide - ENSMUSP00000030878
Ensembl peptide - ENSMUSP00000110830
Ensembl peptide - ENSMUSP00000118029
NCBI entrez gene - 80979     See in Manteia.
MGI - MGI:1933154
RefSeq - XM_006535818
RefSeq - NM_001289787
RefSeq - NM_001289788
RefSeq - NM_030727
RefSeq Peptide - NP_109652
RefSeq Peptide - NP_001276716
RefSeq Peptide - NP_001276717
swissprot - D3Z013
swissprot - D6RIK0
swissprot - Q32MT6
swissprot - Q99NH7
Ensembl - ENSMUSG00000029015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc26a5ENSDARG00000022424Danio rerio
 SLC26A5ENSGALG00000008222Gallus gallus
 P58743ENSG00000170615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325938
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065137
Q9WVC8 / Slc26a3 / Chloride anion exchanger / P40879* / solute carrier family 26 member 3*ENSMUSG0000000122536
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226834
Q62273 / Slc26a2 / Sulfate transporter / P50443* / solute carrier family 26 member 2*ENSMUSG0000003432032
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044129
P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1 / Q9H2B4* / solute carrier family 26 member 1*ENSMUSG0000004695929
Q8R0C3 / Slc26a8 / Testis anion transporter 1 / Q96RN1* / solute carrier family 26 member 8*ENSMUSG0000003619627
Q8R2Z3 / Slc26a7 / Anion exchange transporter / Q8TE54* / solute carrier family 26 member 7*ENSMUSG0000004056926


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR018045  Sulphate anion transporter, conserved site
 IPR030282  Prestin
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008272 sulfate transport IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0009751 response to salicylic acid IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0015755 fructose transmembrane transport IEA
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034766 negative regulation of ion transmembrane transport IEA
 biological_processGO:0035864 response to potassium ion IEA
 biological_processGO:0042391 regulation of membrane potential IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902074 response to salt IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 biological_processGO:2000147 positive regulation of cell motility IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IBA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IBA
 molecular_functionGO:0030507 spectrin binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5mpc234H/Slc26a5mpc234H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004413 absent cochlear microphonics "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004414 decreased cochlear microphonics "reduction of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004430 abnormal Claudius cell morphology "any structural abnormality in the columnar cells located on the floor of the ductus cochlearis external to the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0004435 abnormal cochlear outer hair cell electromotility "anomalous motility of the cochlear OHCs in response to electrical stimulation; normally, the motile response (i.e. rapid change in length and stiffness of OHCs) is closely coupled to the changing transduction current and provides a region-specific amplification in the movement of the spiral organ that enhances transduction at the IHCs in that specific region of the cochlear spiral, increasing both sensitivity and specificity; electromotility is believed to arise through voltage-gated conformational changes in motor protein (prestin) or proteins located in the lateral wall of the OHC" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dicer1Gt(RRF266)Byg/Dicer1Gt(RRF266)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004436 absent cochlear outer hair cell electromotility "absence or loss of motility of the cochlear OHCs in response to electrical stimulation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004437 decreased cochlear outer hair cell electromotility "reduced motility of the cochlear OHCs in response to electrical stimulation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Slc26a5tm3Jnz/Slc26a5tm3Jnz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004466 short cochlear outer hair cells 
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004767 increased cochlear nerve compound action potential "greater combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc26a5tm3Jnz/Slc26a5tm3Jnz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006336 abnormal otoacoustic response "anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz,Tectatm1.1Ogha/Tectatm1.1Ogha
Genetic Background: involves: 129S7/SvEvBrd * CBA

Allelic Composition: Slc26a5tm1Jnz/Slc26a5tm1Jnz,Tectatm1.1Ogha/Tecta+
Genetic Background: involves: 129S7/SvEvBrd * CBA

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Slc26a5tm1Jnz/Slc26a5+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Slc26a5tm4.1(cre/ERT2)Jnz/Slc26a5tm4.1(cre/ERT2)Jnz
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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