ENSMUSG00000046959


Mus musculus

Features
Gene ID: ENSMUSG00000046959
  
Biological name :Slc26a1
  
Synonyms : P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1
  
Possible biological names infered from orthology : Q9H2B4 / solute carrier family 26 member 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 108669878
Gene end: 108675569
  
Corresponding Affymetrix probe sets: 10532241 (MoGene1.0st)   1451239_a_at (Mouse Genome 430 2.0 Array)   1458327_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051561
Ensembl peptide - ENSMUSP00000113185
Ensembl peptide - ENSMUSP00000116540
Ensembl peptide - ENSMUSP00000131282
NCBI entrez gene - 231583     See in Manteia.
MGI - MGI:2385894
RefSeq - XM_017320856
RefSeq - NM_001310691
RefSeq - NM_001310692
RefSeq - NM_174870
RefSeq - XM_006534911
RefSeq - XM_011249441
RefSeq - XM_017320854
RefSeq - XM_017320855
RefSeq Peptide - NP_001297620
RefSeq Peptide - NP_001297621
RefSeq Peptide - NP_777359
swissprot - G5E8U1
swissprot - D3Z4W4
swissprot - P58735
swissprot - Q3UPH6
Ensembl - ENSMUSG00000046959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc26a1ENSDARG00000029832Danio rerio
 SLC26A1ENSGALG00000027423Gallus gallus
 Q9H2B4ENSG00000145217Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62273 / Slc26a2 / Sulfate transporter / P50443* / solute carrier family 26 member 2*ENSMUSG0000003432045
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325931
Q99NH7 / Slc26a5 / Prestin / P58743* / solute carrier family 26 member 5*ENSMUSG0000002901530
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065130
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044130
Q9WVC8 / Slc26a3 / Chloride anion exchanger / P40879* / solute carrier family 26 member 3*ENSMUSG0000000122529
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226827
Q8R2Z3 / Slc26a7 / Anion exchange transporter / Q8TE54* / solute carrier family 26 member 7*ENSMUSG0000004056924
Q8R0C3 / Slc26a8 / Testis anion transporter 1 / Q96RN1* / solute carrier family 26 member 8*ENSMUSG0000003619623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR018045  Sulphate anion transporter, conserved site
 IPR030331  Solute carrier family 26 member 1
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IDA
 biological_processGO:0008272 sulfate transport IDA
 biological_processGO:0015701 bicarbonate transport IBA
 biological_processGO:0019532 oxalate transport IDA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0051453 regulation of intracellular pH IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IBA
 molecular_functionGO:0015108 chloride transmembrane transporter activity IDA
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IDA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IDA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IDA


Pathways (from Reactome)
Pathway description
Transport and synthesis of PAPS
Multifunctional anion exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000192 abnormal mineral level "anomalous concentration of any inorganic substance that has importance in body functions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0002708 kidney stones "calculi occurring in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0002853 hyposulfatemia "abnormally low concentration of sulfate in the circulating blood" [J:86561]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

 MP:0009472 hypersulfaturia "an increase of excretion of sulfates in the urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sec24bkrb/Sec24bkrb
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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