ENSMUSG00000001225


Mus musculus

Features
Gene ID: ENSMUSG00000001225
  
Biological name :Slc26a3
  
Synonyms : Chloride anion exchanger / Q9WVC8 / Slc26a3
  
Possible biological names infered from orthology : P40879 / solute carrier family 26 member 3
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A2
Gene start: 31390871
Gene end: 31473917
  
Corresponding Affymetrix probe sets: 10395201 (MoGene1.0st)   1421445_at (Mouse Genome 430 2.0 Array)   1427547_a_at (Mouse Genome 430 2.0 Array)   1429467_s_at (Mouse Genome 430 2.0 Array)   1453151_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106478
Ensembl peptide - ENSMUSP00000130676
Ensembl peptide - ENSMUSP00000128722
Ensembl peptide - ENSMUSP00000001254
NCBI entrez gene - 13487     See in Manteia.
MGI - MGI:107181
RefSeq - XM_011243812
RefSeq - XM_017314950
RefSeq - NM_021353
RefSeq Peptide - NP_067328
swissprot - Q9WVC8
swissprot - E9QAZ3
swissprot - E9PY22
Ensembl - ENSMUSG00000001225
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc26a3.1ENSDARG00000007371Danio rerio
 slc26a3.2ENSDARG00000003615Danio rerio
 SLC26A3ENSGALG00000007959Gallus gallus
 P40879ENSG00000091138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R155 / Slc26a4 / Pendrin / O43511* / solute carrier family 26 member 4*ENSMUSG0000002065146
Q99NH7 / Slc26a5 / Prestin / P58743* / solute carrier family 26 member 5*ENSMUSG0000002901536
Slc26a6 / solute carrier family 26, member 6 / Q9BXS9*ENSMUSG0000002325934
Slc26a9 / solute carrier family 26 member 9 / Q7LBE3*ENSMUSG0000004226834
Slc26a10 / solute carrier family 26 member 10 / Q8NG04*ENSMUSG0000004044129
Q62273 / Slc26a2 / Sulfate transporter / P50443* / solute carrier family 26 member 2*ENSMUSG0000003432028
Q8R0C3 / Slc26a8 / Testis anion transporter 1 / Q96RN1* / solute carrier family 26 member 8*ENSMUSG0000003619627
P58735 / Slc26a1 / solute carrier family 26 (sulfate transporter), member 1 / Q9H2B4* / solute carrier family 26 member 1*ENSMUSG0000004695927
Q8R2Z3 / Slc26a7 / Anion exchange transporter / Q8TE54* / solute carrier family 26 member 7*ENSMUSG0000004056926


Protein motifs (from Interpro)
Interpro ID Name
 IPR001902  SLC26A/SulP transporter
 IPR002645  STAS domain
 IPR011547  SLC26A/SulP transporter domain
 IPR018045  Sulphate anion transporter, conserved site
 IPR030321  Solute carrier family 26 member 3 (DRA)
 IPR036513  STAS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0008272 sulfate transport IEA
 biological_processGO:0015701 bicarbonate transport IEA
 biological_processGO:0019532 oxalate transport IEA
 biological_processGO:0048240 sperm capacitation IMP
 biological_processGO:0051454 intracellular pH elevation IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060081 membrane hyperpolarization IMP
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0098656 anion transmembrane transport IEA
 biological_processGO:1902358 sulfate transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0097225 sperm midpiece IDA
 molecular_functionGO:0005254 chloride channel activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008271 secondary active sulfate transmembrane transporter activity IEA
 molecular_functionGO:0015106 bicarbonate transmembrane transporter activity IMP
 molecular_functionGO:0015108 chloride transmembrane transporter activity IMP
 molecular_functionGO:0015116 sulfate transmembrane transporter activity IBA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015301 anion:anion antiporter activity IDA
 molecular_functionGO:0019531 oxalate transmembrane transporter activity IBA


Pathways (from Reactome)
Pathway description
Multifunctional anion exchangers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

Allelic Composition: Slc26a3tm1Sole/Slc26a3tm1Sole
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Scarb1tm1.1Thh/Scarb1tm1.1Thh
Genetic Background: B6.129X1-Scarb1tm1.1Thh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr