ENSG00000112658


Homo sapiens

Features
Gene ID: ENSG00000112658
  
Biological name :SRF
  
Synonyms : P11831 / serum response factor / SRF
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 43171299
Gene end: 43181507
  
Corresponding Affymetrix probe sets: 202400_s_at (Human Genome U133 Plus 2.0 Array)   202401_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265354
NCBI entrez gene - 6722     See in Manteia.
OMIM - 600589
RefSeq - NM_001292001
RefSeq - NM_003131
RefSeq Peptide - NP_001278930
RefSeq Peptide - NP_003122
swissprot - P11831
swissprot - A0A024RD16
Ensembl - ENSG00000112658
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srfaENSDARG00000053918Danio rerio
 srfbENSDARG00000102867Danio rerio
 SRFENSGALG00000032029Gallus gallus
 SrfENSMUSG00000015605Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR033897  MADS SRF-like
 IPR036879  Transcription factor, MADS-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001666 response to hypoxia IEP
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001829 trophectodermal cell differentiation IDA
 biological_processGO:0001947 heart looping ISS
 biological_processGO:0002011 morphogenesis of an epithelial sheet IEA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0002521 leukocyte differentiation IEA
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007616 long-term memory IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0009636 response to toxic substance TAS
 biological_processGO:0009725 response to hormone IDA
 biological_processGO:0010669 epithelial structure maintenance IEA
 biological_processGO:0010735 positive regulation of transcription via serum response element binding IDA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030038 contractile actin filament bundle assembly IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0033561 regulation of water loss via skin IEA
 biological_processGO:0034097 response to cytokine NAS
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II ISS
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043589 skin morphogenesis IEA
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IDA
 biological_processGO:0046016 positive regulation of transcription by glucose IEA
 biological_processGO:0046716 muscle cell cellular homeostasis ISS
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048666 neuron development TAS
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051150 regulation of smooth muscle cell differentiation TAS
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0055003 cardiac myofibril assembly IEA
 biological_processGO:0060055 angiogenesis involved in wound healing TAS
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter IDA
 biological_processGO:0060292 long term synaptic depression IEA
 biological_processGO:0060324 face development IEA
 biological_processGO:0060347 heart trabecula formation IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060532 bronchus cartilage development IEA
 biological_processGO:0060534 trachea cartilage development IEA
 biological_processGO:0060947 cardiac vascular smooth muscle cell differentiation IEA
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0061145 lung smooth muscle development IEA
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0090009 primitive streak formation IEA
 biological_processGO:0090136 epithelial cell-cell adhesion IEA
 biological_processGO:0090398 cellular senescence IMP
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900222 negative regulation of amyloid-beta clearance IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISS
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II ISS
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0010736 serum response element binding IDA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070878 primary miRNA binding ISS


Pathways (from Reactome)
Pathway description
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196588 MKL1 / Q969V6 / megakaryoblastic leukemia (translocation) 1  / complex / reaction
 ENSG00000173611 SCAI / Q8N9R8 / suppressor of cancer cell invasion  / complex / reaction






 

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