ENSG00000113360


Homo sapiens

Features
Gene ID: ENSG00000113360
  
Biological name :DROSHA
  
Synonyms : DROSHA / drosha ribonuclease III / Q9NRR4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: p13.3
Gene start: 31400497
Gene end: 31532196
  
Corresponding Affymetrix probe sets: 218269_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428782
Ensembl peptide - ENSP00000425979
Ensembl peptide - ENSP00000430921
Ensembl peptide - ENSP00000339845
Ensembl peptide - ENSP00000409335
Ensembl peptide - ENSP00000422745
Ensembl peptide - ENSP00000424161
NCBI entrez gene - 29102     See in Manteia.
OMIM - 608828
RefSeq - XM_017009402
RefSeq - XM_005248293
RefSeq - XM_005248294
RefSeq - XM_011514033
RefSeq - XM_017009399
RefSeq - XM_017009400
RefSeq - XM_017009401
RefSeq - NM_001100412
RefSeq - NM_013235
RefSeq - XM_005248291
RefSeq - XM_005248292
RefSeq Peptide - NP_001093882
RefSeq Peptide - NP_037367
swissprot - H0YB67
swissprot - H7C5U6
swissprot - Q9NRR4
swissprot - E5RHD1
Ensembl - ENSG00000113360
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnasenENSDARG00000055563Danio rerio
 DROSHAENSGALG00000012916Gallus gallus
 DroshaENSMUSG00000022191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000999  Ribonuclease III domain
 IPR011907  Ribonuclease III
 IPR014720  Double-stranded RNA-binding domain
 IPR036389  Ribonuclease III, endonuclease domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010586 miRNA metabolic process TAS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016075 rRNA catabolic process IEA
 biological_processGO:0030422 production of siRNA involved in RNA interference IBA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031053 primary miRNA processing IMP
 biological_processGO:0031054 pre-miRNA processing IBA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:2000628 regulation of miRNA metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0070877 microprocessor complex IDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003725 double-stranded RNA binding IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IEA
 molecular_functionGO:0004525 ribonuclease III activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding IPI
 molecular_functionGO:0070878 primary miRNA binding NAS


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128191 DGCR8 / Q8WYQ5 / DGCR8, microprocessor complex subunit  / complex






 

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