ENSMUSG00000022191


Mus musculus

Features
Gene ID: ENSMUSG00000022191
  
Biological name :Drosha
  
Synonyms : Drosha / Q5HZJ0 / Ribonuclease 3
  
Possible biological names infered from orthology : drosha ribonuclease III / Q9NRR4
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 12824815
Gene end: 12935291
  
Corresponding Affymetrix probe sets: 10423185 (MoGene1.0st)   1428656_at (Mouse Genome 430 2.0 Array)   1438440_at (Mouse Genome 430 2.0 Array)   1438505_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087762
Ensembl peptide - ENSMUSP00000129279
NCBI entrez gene - 14000     See in Manteia.
MGI - MGI:1261425
RefSeq - XM_006520021
RefSeq - NM_001130149
RefSeq - NM_026799
RefSeq Peptide - NP_081075
RefSeq Peptide - NP_001123621
swissprot - Q5HZJ0
Ensembl - ENSMUSG00000022191
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnasenENSDARG00000055563Danio rerio
 DROSHAENSGALG00000012916Gallus gallus
 DROSHAENSG00000113360Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000999  Ribonuclease III domain
 IPR011907  Ribonuclease III
 IPR014720  Double-stranded RNA-binding domain
 IPR036389  Ribonuclease III, endonuclease domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010586 miRNA metabolic process IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016075 rRNA catabolic process IEA
 biological_processGO:0030422 production of siRNA involved in RNA interference IBA
 biological_processGO:0031053 primary miRNA processing IEA
 biological_processGO:0031054 pre-miRNA processing IDA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0045589 regulation of regulatory T cell differentiation IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:2000628 regulation of miRNA metabolic process IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0070877 microprocessor complex IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IDA
 molecular_functionGO:0004525 ribonuclease III activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:0070878 primary miRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000380 small hair follicles "reduced size of the invagination of the epidermis from which the hair shaft develops" [J:56777]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Droshatm1.1Vlcg/Droshatm3Vlcg,Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1Smr/Dicer1tm1Smr,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rettm1.1Vlcg/Rettm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Droshatm1.1Vlcg/Droshatm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003875 abnormal hair follicle regresssion "abnormal length of time for the onset of catagen phase of the cyclic trasnformation of the hair follicle " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004941 abnormal regulatory T cell morphology "any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ndst1tm1.1Grob/Ndst1tm1.1Grob,Ndst3tm1.1Grob/Ndst3tm1.1Grob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008698 abnormal interleukin-4 secretion "anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Droshatm1Litt/Droshatm1.1Litt,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Acvrl1tm2.1Spo/Acvrl1tm2.1Spo,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
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Allelic Composition: Droshatm1Litt/Droshatm1Litt,Tg(KRT5-rtTA)1Glk/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Droshatm1.1Vlcg/Droshatm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Droshatm3Vlcg/Droshatm3Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Nr1h4tm1.1Gonz/Nr1h4tm1.1Gonz,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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