ENSG00000115053


Homo sapiens

Features
Gene ID: ENSG00000115053
  
Biological name :NCL
  
Synonyms : NCL / nucleolin / P19338
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.1
Gene start: 231453531
Gene end: 231483641
  
Corresponding Affymetrix probe sets: 200610_s_at (Human Genome U133 Plus 2.0 Array)   241892_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401620
Ensembl peptide - ENSP00000349410
Ensembl peptide - ENSP00000413775
Ensembl peptide - ENSP00000318195
Ensembl peptide - ENSP00000401322
Ensembl peptide - ENSP00000392747
NCBI entrez gene - 4691     See in Manteia.
OMIM - 164035
RefSeq - NM_005381
RefSeq Peptide - NP_005372
swissprot - C9JLB1
swissprot - C9J1H7
swissprot - A0A024R4A0
swissprot - H7BY16
swissprot - C9JYW2
swissprot - P19338
swissprot - C9JWL1
Ensembl - ENSG00000115053
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nclENSDARG00000002710Danio rerio
 NCLENSGALG00000032930Gallus gallus
 NclENSMUSG00000026234Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR003954  RNA recognition motif domain, eukaryote
 IPR034230  Nucleolin, RNA recognition motif 1
 IPR034233  Nucleolin, RNA recognition motif 2
 IPR034234  Nucleolin, RNA recognition motif 3
 IPR034235  Nucleolin, RNA recognition motif 4
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044547 DNA topoisomerase binding IPI
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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