ENSG00000115419


Homo sapiens

Features
Gene ID: ENSG00000115419
  
Biological name :GLS
  
Synonyms : GLS / glutaminase / O94925
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q32.2
Gene start: 190880827
Gene end: 190965552
  
Corresponding Affymetrix probe sets: 203157_s_at (Human Genome U133 Plus 2.0 Array)   203158_s_at (Human Genome U133 Plus 2.0 Array)   203159_at (Human Genome U133 Plus 2.0 Array)   211414_at (Human Genome U133 Plus 2.0 Array)   221510_s_at (Human Genome U133 Plus 2.0 Array)   223079_s_at (Human Genome U133 Plus 2.0 Array)   223080_at (Human Genome U133 Plus 2.0 Array)   241034_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386417
Ensembl peptide - ENSP00000387135
Ensembl peptide - ENSP00000403329
Ensembl peptide - ENSP00000395596
Ensembl peptide - ENSP00000388990
Ensembl peptide - ENSP00000387177
Ensembl peptide - ENSP00000317379
Ensembl peptide - ENSP00000340689
NCBI entrez gene - 2744     See in Manteia.
OMIM - 138280
RefSeq - XM_006712435
RefSeq - NM_001256310
RefSeq - NM_014905
RefSeq - XM_005246467
RefSeq Peptide - NP_055720
RefSeq Peptide - NP_001243239
swissprot - O94925
swissprot - C9JIJ6
swissprot - B8ZZC5
swissprot - B8ZZA8
swissprot - H7BZD1
swissprot - B7Z509
swissprot - H7C201
Ensembl - ENSG00000115419
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glsaENSDARG00000062812Danio rerio
 glsbENSDARG00000040705Danio rerio
 GLSENSGALG00000030419Gallus gallus
 GlsENSMUSG00000026103Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLS2 / Q9UI32 / glutaminase 2ENSG0000013542359


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR012338  Beta-lactamase/transpeptidase-like
 IPR015868  Glutaminase
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA
 biological_processGO:0006537 glutamate biosynthetic process TAS
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006543 glutamine catabolic process NAS
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process TAS
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0051289 protein homotetramerization IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004359 glutaminase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle
TP53 Regulates Metabolic Genes
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115419 GLS / O94925 / glutaminase  / complex






 

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