ENSMUSG00000026103


Mus musculus

Features
Gene ID: ENSMUSG00000026103
  
Biological name :Gls
  
Synonyms : D3Z7P3 / Gls / Glutaminase kidney isoform, mitochondrial
  
Possible biological names infered from orthology : glutaminase / O94925
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C1.1
Gene start: 52163448
Gene end: 52233232
  
Corresponding Affymetrix probe sets: 10354472 (MoGene1.0st)   1434657_at (Mouse Genome 430 2.0 Array)   1436299_at (Mouse Genome 430 2.0 Array)   1438827_at (Mouse Genome 430 2.0 Array)   1457211_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116901
Ensembl peptide - ENSMUSP00000115358
Ensembl peptide - ENSMUSP00000121408
Ensembl peptide - ENSMUSP00000110155
Ensembl peptide - ENSMUSP00000110157
Ensembl peptide - ENSMUSP00000110158
NCBI entrez gene - 14660     See in Manteia.
MGI - MGI:95752
RefSeq - XM_017316236
RefSeq - NM_001081081
RefSeq - NM_001113383
RefSeq - XM_006495701
RefSeq - XM_006495702
RefSeq - XM_006495703
RefSeq Peptide - NP_001074550
RefSeq Peptide - NP_001106854
swissprot - D3Z7P3
swissprot - F7B327
swissprot - D3Z7P4
swissprot - F6U529
swissprot - F6RDM4
Ensembl - ENSMUSG00000026103
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 glsaENSDARG00000062812Danio rerio
 glsbENSDARG00000040705Danio rerio
 GLSENSGALG00000030419Gallus gallus
 GLSENSG00000115419Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gls2 / Q571F8 / Glutaminase liver isoform, mitochondrial / Q9UI32* / glutaminase 2*ENSMUSG0000004400559


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR012338  Beta-lactamase/transpeptidase-like
 IPR015868  Glutaminase
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0002087 regulation of respiratory gaseous exchange by neurological system process IMP
 biological_processGO:0006537 glutamate biosynthetic process IDA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006543 glutamine catabolic process IDA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0051289 protein homotetramerization ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004359 glutaminase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle
TP53 Regulates Metabolic Genes
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(Prrx1-FUS/DDIT3)1Mete/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpr37l1tm1d(EUCOMM)Wtsi/Gpr37l1+
Genetic Background: involves: BALB/cJ * C57BL/6N * SJL

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

 MP:0030586 impaired behavioral response to amphetamine "decreased sensitivity to amphetamine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:anna]
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Allelic Composition: Foxo1tm1Rdp/Foxo1tm1.1Rdp,Foxo3tm1Rdp/Foxo3tm1.1Rdp,Ptentm1Hwu/Ptentm1Hwu,Tg(CYP19A1-cre)1Jri/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026103 Gls / D3Z7P3 / Glutaminase kidney isoform, mitochondrial / O94925* / glutaminase*  / complex






 

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