ENSG00000135423


Homo sapiens

Features
Gene ID: ENSG00000135423
  
Biological name :GLS2
  
Synonyms : GLS2 / glutaminase 2 / Q9UI32
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 56470944
Gene end: 56488414
  
Corresponding Affymetrix probe sets: 1564705_at (Human Genome U133 Plus 2.0 Array)   1564706_s_at (Human Genome U133 Plus 2.0 Array)   1564707_x_at (Human Genome U133 Plus 2.0 Array)   205531_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419661
Ensembl peptide - ENSP00000485315
Ensembl peptide - ENSP00000483010
Ensembl peptide - ENSP00000441739
Ensembl peptide - ENSP00000420328
Ensembl peptide - ENSP00000419996
Ensembl peptide - ENSP00000310447
Ensembl peptide - ENSP00000416282
Ensembl peptide - ENSP00000417244
Ensembl peptide - ENSP00000417723
Ensembl peptide - ENSP00000417796
NCBI entrez gene - 27165     See in Manteia.
OMIM - 606365
RefSeq - XM_017019180
RefSeq - NM_001280796
RefSeq - NM_001280797
RefSeq - NM_001280798
RefSeq - NM_013267
RefSeq - XM_005268797
RefSeq Peptide - NP_037399
RefSeq Peptide - NP_001267725
RefSeq Peptide - NP_001267726
RefSeq Peptide - NP_001267727
swissprot - A8K0A6
swissprot - A0A087X004
swissprot - C9J3Q2
swissprot - F8WBC9
swissprot - F8WEU7
swissprot - F8WBL8
swissprot - G5E9X4
swissprot - Q9UI32
swissprot - E5G745
Ensembl - ENSG00000135423
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gls2aENSDARG00000069095Danio rerio
 gls2bENSDARG00000002917Danio rerio
 Gls2ENSMUSG00000044005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLS / O94925 / glutaminaseENSG0000011541966


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR012338  Beta-lactamase/transpeptidase-like
 IPR015868  Glutaminase
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process TAS
 biological_processGO:0006537 glutamate biosynthetic process IBA
 biological_processGO:0006541 glutamine metabolic process IEA
 biological_processGO:0006543 glutamine catabolic process IBA
 biological_processGO:0008652 cellular amino acid biosynthetic process TAS
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0004359 glutaminase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle
TP53 Regulates Metabolic Genes
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135423 GLS2 / Q9UI32 / glutaminase 2  / complex






 

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