ENSG00000116406


Homo sapiens

Features
Gene ID: ENSG00000116406
  
Biological name :EDEM3
  
Synonyms : EDEM3 / ER degradation enhancing alpha-mannosidase like protein 3 / Q9BZQ6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q25.3
Gene start: 184690231
Gene end: 184754913
  
Corresponding Affymetrix probe sets: 220342_x_at (Human Genome U133 Plus 2.0 Array)   220926_s_at (Human Genome U133 Plus 2.0 Array)   223243_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390536
Ensembl peptide - ENSP00000318147
Ensembl peptide - ENSP00000356482
NCBI entrez gene - 80267     See in Manteia.
OMIM - 610214
RefSeq - XM_017002398
RefSeq - XM_005245499
RefSeq - XM_011510012
RefSeq - XM_011510013
RefSeq - XM_011510014
RefSeq - XM_017002397
RefSeq - NM_001319960
RefSeq - NM_025191
RefSeq Peptide - NP_001306889
RefSeq Peptide - NP_079467
swissprot - H0Y498
swissprot - Q9BZQ6
swissprot - A0A024R931
Ensembl - ENSG00000116406
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edem3ENSDARG00000074129Danio rerio
 EDEM3ENSGALG00000004806Gallus gallus
 Edem3ENSMUSG00000043019Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDEM1 / Q92611 / ER degradation enhancing alpha-mannosidase like protein 1ENSG0000013410924
EDEM2 / Q9BV94 / ER degradation enhancing alpha-mannosidase like protein 2ENSG0000008829823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR003137  PA domain
 IPR036026  Seven-hairpin glycosidases
 IPR037322  EDEM3, PA domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0006516 glycoprotein catabolic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:1904382 mannose trimming involved in glycoprotein ERAD pathway TAS
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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