ENSG00000088298


Homo sapiens

Features
Gene ID: ENSG00000088298
  
Biological name :EDEM2
  
Synonyms : EDEM2 / ER degradation enhancing alpha-mannosidase like protein 2 / Q9BV94
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.22
Gene start: 35115357
Gene end: 35147364
  
Corresponding Affymetrix probe sets: 218282_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000363615
Ensembl peptide - ENSP00000363616
NCBI entrez gene - 55741     See in Manteia.
OMIM - 610302
RefSeq - NM_001145025
RefSeq - NM_018217
RefSeq Peptide - NP_001138497
RefSeq Peptide - NP_060687
swissprot - Q9BV94
Ensembl - ENSG00000088298
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edem2ENSDARG00000028448Danio rerio
 EDEM2ENSGALG00000003128Gallus gallus
 Edem2ENSMUSG00000038312Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDEM3 / Q9BZQ6 / ER degradation enhancing alpha-mannosidase like protein 3ENSG0000011640638
EDEM1 / Q92611 / ER degradation enhancing alpha-mannosidase like protein 1ENSG0000013410937


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IBA
 biological_processGO:0036509 trimming of terminal mannose on B branch TAS
 biological_processGO:0036510 trimming of terminal mannose on C branch TAS
 biological_processGO:0036511 trimming of first mannose on A branch TAS
 biological_processGO:0036512 trimming of second mannose on A branch TAS
 biological_processGO:0097466 ubiquitin-dependent glycoprotein ERAD pathway IMP
 biological_processGO:1904154 positive regulation of retrograde protein transport, ER to cytosol IEA
 biological_processGO:1904382 mannose trimming involved in glycoprotein ERAD pathway IMP
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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