ENSG00000134109


Homo sapiens

Features
Gene ID: ENSG00000134109
  
Biological name :EDEM1
  
Synonyms : EDEM1 / ER degradation enhancing alpha-mannosidase like protein 1 / Q92611
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p26.1
Gene start: 5187646
Gene end: 5219957
  
Corresponding Affymetrix probe sets: 203279_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394615
Ensembl peptide - ENSP00000256497
Ensembl peptide - ENSP00000393659
Ensembl peptide - ENSP00000394099
NCBI entrez gene - 9695     See in Manteia.
OMIM - 607673
RefSeq - XM_011534272
RefSeq - NM_014674
RefSeq - XM_011534271
RefSeq Peptide - NP_055489
swissprot - A0A024R2D5
swissprot - Q92611
swissprot - F8WE67
swissprot - F8WER9
Ensembl - ENSG00000134109
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edem1ENSDARG00000025094Danio rerio
 EDEM1ENSGALG00000008320Gallus gallus
 Edem1ENSMUSG00000030104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDEM3 / Q9BZQ6 / ER degradation enhancing alpha-mannosidase like protein 3ENSG0000011640634
EDEM2 / Q9BV94 / ER degradation enhancing alpha-mannosidase like protein 2ENSG0000008829833


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway ISS
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0036510 trimming of terminal mannose on C branch IEA
 biological_processGO:0097466 ubiquitin-dependent glycoprotein ERAD pathway IMP
 biological_processGO:1904154 positive regulation of retrograde protein transport, ER to cytosol IMP
 biological_processGO:1904382 mannose trimming involved in glycoprotein ERAD pathway TAS
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISS
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0051787 misfolded protein binding IDA


Pathways (from Reactome)
Pathway description
XBP1(S) activates chaperone genes
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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