ENSMUSG00000030104


Mus musculus

Features
Gene ID: ENSMUSG00000030104
  
Biological name :Edem1
  
Synonyms : Edem1 / ER degradation-enhancing alpha-mannosidase-like protein 1 / Q925U4
  
Possible biological names infered from orthology : Q92611
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E2
Gene start: 108828641
Gene end: 108859356
  
Corresponding Affymetrix probe sets: 10540493 (MoGene1.0st)   1424065_at (Mouse Genome 430 2.0 Array)   1451218_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144901
Ensembl peptide - ENSMUSP00000086565
NCBI entrez gene - 192193     See in Manteia.
MGI - MGI:2180139
RefSeq - NM_138677
RefSeq - XM_006505746
RefSeq Peptide - NP_619618
swissprot - A0A0N4SV08
swissprot - Q925U4
Ensembl - ENSMUSG00000030104
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edem1ENSDARG00000025094Danio rerio
 EDEM1ENSGALG00000008320Gallus gallus
 EDEM1ENSG00000134109Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Edem3 / Q2HXL6 / ER degradation-enhancing alpha-mannosidase-like protein 3 / Q9BZQ6*ENSMUSG0000004301934
Edem2 / ER degradation enhancing alpha-mannosidase like protein 2 / Q9BV94*ENSMUSG0000003831233


Protein motifs (from Interpro)
Interpro ID Name
 IPR001382  Glycoside hydrolase family 47
 IPR036026  Seven-hairpin glycosidases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006491 N-glycan processing IBA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IDA
 biological_processGO:0036510 trimming of terminal mannose on C branch IMP
 biological_processGO:0097466 ubiquitin-dependent glycoprotein ERAD pathway IEA
 biological_processGO:1904154 positive regulation of retrograde protein transport, ER to cytosol IEA
 biological_processGO:1904382 mannose trimming involved in glycoprotein ERAD pathway IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0051787 misfolded protein binding IEA


Pathways (from Reactome)
Pathway description
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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