ENSG00000116604


Homo sapiens

Features
Gene ID: ENSG00000116604
  
Biological name :MEF2D
  
Synonyms : MEF2D / myocyte enhancer factor 2D / Q14814
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q22
Gene start: 156463727
Gene end: 156500828
  
Corresponding Affymetrix probe sets: 203003_at (Human Genome U133 Plus 2.0 Array)   203004_s_at (Human Genome U133 Plus 2.0 Array)   225641_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477124
Ensembl peptide - ENSP00000476788
Ensembl peptide - ENSP00000477413
Ensembl peptide - ENSP00000271555
Ensembl peptide - ENSP00000353803
Ensembl peptide - ENSP00000357223
NCBI entrez gene - 4209     See in Manteia.
OMIM - 600663
RefSeq - XM_017001315
RefSeq - NM_001271629
RefSeq - NM_005920
RefSeq - XM_006711332
RefSeq - XM_006711333
RefSeq - XM_006711334
RefSeq - XM_011509569
RefSeq - XM_017001314
RefSeq - XM_005245169
RefSeq - XM_005245170
RefSeq - XM_006711330
RefSeq Peptide - NP_001258558
RefSeq Peptide - NP_005911
swissprot - Q05BX2
swissprot - Q14814
swissprot - A0A0G2JLL8
Ensembl - ENSG00000116604
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mef2dENSDARG00000040237Danio rerio
 MEF2DENSGALG00000037787Gallus gallus
 Mef2dENSMUSG00000001419Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MEF2A / Q02078 / myocyte enhancer factor 2AENSG0000006830553
MEF2C / Q06413 / myocyte enhancer factor 2CENSG0000008118948
MEF2B / Q02080 / myocyte enhancer factor 2BENSG0000021399929
BORCS8-MEF2B / BORCS8-MEF2B readthroughENSG0000006448926


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR022102  Holliday junction regulator protein family C-terminal
 IPR033896  MADS MEF2-like
 IPR036879  Transcription factor, MADS-box superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007512 adult heart development IEP
 biological_processGO:0007517 muscle organ development TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
CDO in myogenesis
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr