ENSG00000117222


Homo sapiens

Features
Gene ID: ENSG00000117222
  
Biological name :RBBP5
  
Synonyms : Q15291 / RB binding protein 5, histone lysine methyltransferase complex subunit / RBBP5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 205086142
Gene end: 205122015
  
Corresponding Affymetrix probe sets: 205169_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356132
Ensembl peptide - ENSP00000264515
NCBI entrez gene - 5929     See in Manteia.
OMIM - 600697
RefSeq - XM_011509833
RefSeq - NM_001193272
RefSeq - NM_001193273
RefSeq - NM_005057
RefSeq Peptide - NP_001180201
RefSeq Peptide - NP_001180202
RefSeq Peptide - NP_005048
swissprot - Q15291
swissprot - A0A024R9B5
Ensembl - ENSG00000117222
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbbp5ENSDARG00000042147Danio rerio
 RBBP5ENSGALG00000000668Gallus gallus
 Rbbp5ENSMUSG00000026439Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0043627 response to estrogen IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0051568 histone H3-K4 methylation IDA
 biological_processGO:1904837 beta-catenin-TCF complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0035097 histone methyltransferase complex IPI
 cellular_componentGO:0044666 MLL3/4 complex IDA
 cellular_componentGO:0048188 Set1C/COMPASS complex IDA
 cellular_componentGO:0071339 MLL1 complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0018024 histone-lysine N-methyltransferase activity TAS
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0042800 histone methyltransferase activity (H3-K4 specific) IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
Formation of the beta-catenin:TCF transactivating complex
PKMTs methylate histone lysines
Deactivation of the beta-catenin transactivating complex
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr