ENSG00000120438


Homo sapiens

Features
Gene ID: ENSG00000120438
  
Biological name :TCP1
  
Synonyms : P17987 / t-complex 1 / TCP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.3
Gene start: 159778498
Gene end: 159789749
  
Corresponding Affymetrix probe sets: 208778_s_at (Human Genome U133 Plus 2.0 Array)   222010_at (Human Genome U133 Plus 2.0 Array)   222011_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441345
Ensembl peptide - ENSP00000442185
Ensembl peptide - ENSP00000444423
Ensembl peptide - ENSP00000442856
Ensembl peptide - ENSP00000317334
Ensembl peptide - ENSP00000376008
Ensembl peptide - ENSP00000390159
Ensembl peptide - ENSP00000437840
Ensembl peptide - ENSP00000439447
Ensembl peptide - ENSP00000439671
Ensembl peptide - ENSP00000440617
NCBI entrez gene - 6950     See in Manteia.
OMIM - 186980
RefSeq - NM_030752
RefSeq - NM_001008897
RefSeq Peptide - NP_001008897
RefSeq Peptide - NP_110379
swissprot - F5GZI8
swissprot - F5H136
swissprot - F5H282
swissprot - F5H676
swissprot - F5H726
swissprot - F5H7Y1
swissprot - E7ERF2
swissprot - P17987
swissprot - E7EQR6
swissprot - F5GYL4
swissprot - F5GZ03
Ensembl - ENSG00000120438
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tcp1ENSDARG00000017891Danio rerio
 TCP1ENSGALG00000011637Gallus gallus
 Tcp1ENSMUSG00000068039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002194  Chaperonin TCP-1, conserved site
 IPR002423  Chaperonin Cpn60/TCP-1 family
 IPR012715  T-complex protein 1, alpha subunit
 IPR017998  Chaperone tailless complex polypeptide 1 (TCP-1)
 IPR027409  GroEL-like apical domain superfamily
 IPR027410  TCP-1-like chaperonin intermediate domain superfamily
 IPR027413  GroEL-like equatorial domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006458 "de novo" protein folding IBA
 biological_processGO:0007021 tubulin complex assembly NAS
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0044053 translocation of peptides or proteins into host cell cytoplasm IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0090666 scaRNA localization to Cajal body IMP
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1904851 positive regulation of establishment of protein localization to telomere IMP
 biological_processGO:1904871 positive regulation of protein localization to Cajal body IMP
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP
 biological_processGO:2000109 regulation of macrophage apoptotic process IEA
 cellular_componentGO:0000242 pericentriolar material IEA
 cellular_componentGO:0000792 heterochromatin IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0002199 zona pellucida receptor complex IEA
 cellular_componentGO:0005720 nuclear heterochromatin IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005832 chaperonin-containing T-complex IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0044183 protein binding involved in protein folding IBA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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