ENSG00000123453


Homo sapiens

Features
Gene ID: ENSG00000123453
  
Biological name :SARDH
  
Synonyms : Q9UL12 / sarcosine dehydrogenase / SARDH
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.2
Gene start: 133663560
Gene end: 133739955
  
Corresponding Affymetrix probe sets: 207889_at (Human Genome U133 Plus 2.0 Array)   210063_at (Human Genome U133 Plus 2.0 Array)   210862_s_at (Human Genome U133 Plus 2.0 Array)   211322_s_at (Human Genome U133 Plus 2.0 Array)   234536_at (Human Genome U133 Plus 2.0 Array)   234586_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403084
Ensembl peptide - ENSP00000394210
Ensembl peptide - ENSP00000415537
Ensembl peptide - ENSP00000298628
Ensembl peptide - ENSP00000360933
Ensembl peptide - ENSP00000360934
Ensembl peptide - ENSP00000360938
NCBI entrez gene - 1757     See in Manteia.
OMIM - 604455
RefSeq - XM_017014368
RefSeq - NM_001134707
RefSeq - NM_007101
RefSeq - XM_017014367
RefSeq Peptide - NP_009032
RefSeq Peptide - NP_001128179
swissprot - Q5SYV1
swissprot - Q5SYV2
swissprot - Q9UL10
swissprot - Q9UL12
swissprot - A0A0A0MT55
swissprot - Q5SYU9
Ensembl - ENSG00000123453
  
Related genetic diseases (OMIM): 268900 - [Sarcosinemia], 268900
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sardhENSDARG00000058102Danio rerio
 SARDHENSGALG00000002855Gallus gallus
 SardhENSMUSG00000009614Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDPR / Q8NCN5 / pyruvate dehydrogenase phosphatase regulatory subunitENSG0000009085731
DMGDH / Q9UI17 / dimethylglycine dehydrogenaseENSG0000013283731
AMT / P48728 / aminomethyltransferaseENSG0000014502010


Protein motifs (from Interpro)
Interpro ID Name
 IPR006076  FAD dependent oxidoreductase
 IPR006222  Aminomethyltransferase, folate-binding domain
 IPR013977  Glycine cleavage T-protein, C-terminal barrel domain
 IPR028896  Aminomethyltransferase-like
 IPR029043  Glycine cleavage T-protein/YgfZ, C-terminal
 IPR032503  FAD dependent oxidoreductase, central domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0042426 choline catabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1901053 sarcosine catabolic process IBA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005759 mitochondrial matrix NAS
 molecular_functionGO:0008480 sarcosine dehydrogenase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Choline catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr