ENSG00000090857


Homo sapiens

Features
Gene ID: ENSG00000090857
  
Biological name :PDPR
  
Synonyms : PDPR / pyruvate dehydrogenase phosphatase regulatory subunit / Q8NCN5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 70113626
Gene end: 70162537
  
Corresponding Affymetrix probe sets: 220236_at (Human Genome U133 Plus 2.0 Array)   224902_at (Human Genome U133 Plus 2.0 Array)   224904_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457636
Ensembl peptide - ENSP00000457484
Ensembl peptide - ENSP00000457916
Ensembl peptide - ENSP00000457961
Ensembl peptide - ENSP00000288050
Ensembl peptide - ENSP00000381190
Ensembl peptide - ENSP00000455764
Ensembl peptide - ENSP00000456385
Ensembl peptide - ENSP00000456959
NCBI entrez gene - 55066     See in Manteia.
OMIM - 617835
RefSeq - XM_017023389
RefSeq - NM_001322117
RefSeq - NM_001322118
RefSeq - NM_001322119
RefSeq - NM_017990
RefSeq - XM_005256015
RefSeq - XM_005256016
RefSeq - XM_006721224
RefSeq - XM_006721225
RefSeq - XM_011523190
RefSeq - XM_017023387
RefSeq - XM_017023388
RefSeq Peptide - NP_001309047
RefSeq Peptide - NP_001309048
RefSeq Peptide - NP_060460
RefSeq Peptide - NP_001309046
swissprot - H3BU60
swissprot - H3BUH3
swissprot - H3BV59
swissprot - Q8NCN5
swissprot - A8MT40
swissprot - B7ZAR9
swissprot - H3BQG3
swissprot - H3BRS5
Ensembl - ENSG00000090857
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PDPRENSDARG00000103288Danio rerio
 PDPRENSGALG00000002690Gallus gallus
 PdprENSMUSG00000033624Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SARDH / Q9UL12 / sarcosine dehydrogenaseENSG0000012345332
DMGDH / Q9UI17 / dimethylglycine dehydrogenaseENSG0000013283729
AMT / P48728 / aminomethyltransferaseENSG0000014502010


Protein motifs (from Interpro)
Interpro ID Name
 IPR006076  FAD dependent oxidoreductase
 IPR006222  Aminomethyltransferase, folate-binding domain
 IPR013977  Glycine cleavage T-protein, C-terminal barrel domain
 IPR029043  Glycine cleavage T-protein/YgfZ, C-terminal
 IPR032503  FAD dependent oxidoreductase, central domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity EXP
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172840 PDP2 / Q9P2J9 / pyruvate dehyrogenase phosphatase catalytic subunit 2  / complex
 ENSG00000164951 PDP1 / Q9P0J1 / pyruvate dehyrogenase phosphatase catalytic subunit 1  / complex






 

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