ENSG00000172840


Homo sapiens

Features
Gene ID: ENSG00000172840
  
Biological name :PDP2
  
Synonyms : PDP2 / pyruvate dehyrogenase phosphatase catalytic subunit 2 / Q9P2J9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q22.1
Gene start: 66878589
Gene end: 66895754
  
Corresponding Affymetrix probe sets: 226855_at (Human Genome U133 Plus 2.0 Array)   232861_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457951
Ensembl peptide - ENSP00000456611
Ensembl peptide - ENSP00000457331
Ensembl peptide - ENSP00000309548
Ensembl peptide - ENSP00000455975
Ensembl peptide - ENSP00000456171
NCBI entrez gene - 57546     See in Manteia.
OMIM - 615499
RefSeq - XM_017023506
RefSeq - NM_001329928
RefSeq - NM_001329929
RefSeq - NM_001329930
RefSeq - NM_001329931
RefSeq - NM_001329932
RefSeq - NM_001329933
RefSeq - NM_001329934
RefSeq - NM_020786
RefSeq - XM_005256064
RefSeq - XM_005256066
RefSeq - XM_005256067
RefSeq - XM_005256068
RefSeq Peptide - NP_001316857
RefSeq Peptide - NP_001316858
RefSeq Peptide - NP_001316859
RefSeq Peptide - NP_001316860
RefSeq Peptide - NP_001316861
RefSeq Peptide - NP_001316862
RefSeq Peptide - NP_001316863
RefSeq Peptide - NP_065837
swissprot - H3BRB7
swissprot - H3BSA5
swissprot - H3BTU5
swissprot - H3BV50
swissprot - Q9P2J9
swissprot - H3BQX2
Ensembl - ENSG00000172840
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdp2ENSDARG00000058571Danio rerio
 PDP2ENSGALG00000005146Gallus gallus
 Pdp2ENSMUSG00000048371Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDP1 / Q9P0J1 / pyruvate dehyrogenase phosphatase catalytic subunit 1ENSG0000016495148


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090857 PDPR / Q8NCN5 / pyruvate dehydrogenase phosphatase regulatory subunit  / complex






 

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