ENSG00000123737


Homo sapiens

Features
Gene ID: ENSG00000123737
  
Biological name :EXOSC9
  
Synonyms : EXOSC9 / exosome component 9 / Q06265
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q27
Gene start: 121801317
Gene end: 121817021
  
Corresponding Affymetrix probe sets: 205061_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368984
Ensembl peptide - ENSP00000425782
Ensembl peptide - ENSP00000424504
Ensembl peptide - ENSP00000423476
Ensembl peptide - ENSP00000422205
Ensembl peptide - ENSP00000421845
Ensembl peptide - ENSP00000243498
NCBI entrez gene - 5393     See in Manteia.
OMIM - 606180
RefSeq - XM_011532035
RefSeq - NM_001034194
RefSeq - NM_005033
RefSeq Peptide - NP_001029366
RefSeq Peptide - NP_005024
swissprot - Q06265
swissprot - D6RIY6
swissprot - D6RA17
swissprot - D6RAP4
swissprot - D6R905
swissprot - H0Y9L5
Ensembl - ENSG00000123737
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc9ENSDARG00000006392Danio rerio
 EXOSC9ENSGALG00000011884Gallus gallus
 Exosc9ENSMUSG00000027714Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EXOSC7 / Q15024 / exosome component 7ENSG0000007591416
EXOSC8 / Q96B26 / exosome component 8ENSG0000012069916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR033100  Exosome complex component RRP45
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034473 U1 snRNA 3"-end processing IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0034476 U5 snRNA 3"-end processing IBA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071028 nuclear mRNA surveillance IMP
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IMP
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) NAS
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity NAS
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003723 RNA binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IDA


Pathways (from Reactome)
Pathway description
ATF4 activates genes
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr