ENSMUSG00000027714


Mus musculus

Features
Gene ID: ENSMUSG00000027714
  
Biological name :Exosc9
  
Synonyms : Exosc9 / Exosome complex component RRP45 / Q9JHI7
  
Possible biological names infered from orthology : exosome component 9 / Q06265
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 36552606
Gene end: 36565727
  
Corresponding Affymetrix probe sets: 10491551 (MoGene1.0st)   1418462_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117235
Ensembl peptide - ENSMUSP00000143326
Ensembl peptide - ENSMUSP00000122189
Ensembl peptide - ENSMUSP00000121047
Ensembl peptide - ENSMUSP00000029269
NCBI entrez gene - 50911     See in Manteia.
MGI - MGI:1355319
RefSeq - NM_019393
RefSeq Peptide - NP_062266
swissprot - F6Y747
swissprot - D6RGB5
swissprot - Q9JHI7
swissprot - D3YTN9
swissprot - A0A0G2JFV9
Ensembl - ENSMUSG00000027714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc9ENSDARG00000006392Danio rerio
 EXOSC9ENSGALG00000011884Gallus gallus
 EXOSC9ENSG00000123737Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Exosc7 / Q9D0M0 / Exosome complex exonuclease RRP42 / Q15024* / exosome component 7*ENSMUSG0000002578518
Exosc8 / Q9D753 / Exosome complex component RRP43 / Q96B26* / exosome component 8*ENSMUSG0000002775216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR033100  Exosome complex component RRP45
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034473 U1 snRNA 3"-end processing IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0034476 U5 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071028 nuclear mRNA surveillance IEA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IEA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IEA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017091 AU-rich element binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Dolkem1(IMPC)J/Dolkem1(IMPC)J
Genetic Background: C57BL/6NJ-Dolkem1(IMPC)J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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