ENSMUSG00000027752


Mus musculus

Features
Gene ID: ENSMUSG00000027752
  
Biological name :Exosc8
  
Synonyms : Exosc8 / Exosome complex component RRP43 / Q9D753
  
Possible biological names infered from orthology : exosome component 8 / Q96B26
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: C
Gene start: 54728678
Gene end: 54735393
  
Corresponding Affymetrix probe sets: 10498168 (MoGene1.0st)   1420115_at (Mouse Genome 430 2.0 Array)   1428291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118780
Ensembl peptide - ENSMUSP00000029316
Ensembl peptide - ENSMUSP00000115876
NCBI entrez gene - 69639     See in Manteia.
MGI - MGI:1916889
RefSeq - NM_001163570
RefSeq - NM_027148
RefSeq Peptide - NP_001157042
RefSeq Peptide - NP_081424
swissprot - Q9D753
swissprot - D3YYN3
swissprot - Q546F8
swissprot - F6SGT4
Ensembl - ENSMUSG00000027752
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc8ENSDARG00000068755Danio rerio
 EXOSC8ENSGALG00000017048Gallus gallus
 EXOSC8ENSG00000120699Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Exosc7 / Q9D0M0 / Exosome complex exonuclease RRP42 / Q15024* / exosome component 7*ENSMUSG0000002578528
Exosc9 / Q9JHI7 / Exosome complex component RRP45 / Q06265* / exosome component 9*ENSMUSG0000002771426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR033196  Exosome complex component Rrp43
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034473 U1 snRNA 3"-end processing IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0034476 U5 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0017091 AU-rich element binding IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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