ENSMUSG00000025785


Mus musculus

Features
Gene ID: ENSMUSG00000025785
  
Biological name :Exosc7
  
Synonyms : Exosc7 / Exosome complex exonuclease RRP42 / Q9D0M0
  
Possible biological names infered from orthology : exosome component 7 / Q15024
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 123113215
Gene end: 123136129
  
Corresponding Affymetrix probe sets: 10590549 (MoGene1.0st)   1448365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150152
Ensembl peptide - ENSMUSP00000026891
NCBI entrez gene - 66446     See in Manteia.
MGI - MGI:1913696
RefSeq - NM_001081188
RefSeq - XM_006512208
RefSeq Peptide - NP_001074657
swissprot - A0A1L1ST25
swissprot - Q9D0M0
Ensembl - ENSMUSG00000025785
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc7ENSDARG00000100060Danio rerio
 EXOSC7ENSGALG00000030084Gallus gallus
 EXOSC7ENSG00000075914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Exosc9 / Q9JHI7 / Exosome complex component RRP45 / Q06265* / exosome component 9*ENSMUSG0000002771427
Exosc8 / Q9D753 / Exosome complex component RRP43 / Q96B26* / exosome component 8*ENSMUSG0000002775226


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034473 U1 snRNA 3"-end processing IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0034476 U5 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0017091 AU-rich element binding IBA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr