ENSDARG00000068755


Danio rerio

Features
Gene ID: ENSDARG00000068755
  
Biological name :exosc8
  
Synonyms : exosc8 / exosome component 8
  
Possible biological names infered from orthology : Exosome complex component RRP43 / Q96B26 / Q9D753
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 35002786
Gene end: 35011502
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000090326
NCBI entrez gene - 323016     See in Manteia.
RefSeq - NM_001002865
RefSeq Peptide - NP_001002865
swissprot - Q4VBT6
ZFIN ID - ZDB-GENE-030131-1736
Ensembl - ENSDARG00000068755
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EXOSC8ENSGALG00000017048Gallus gallus
 EXOSC8ENSG00000120699Homo sapiens
 Exosc8ENSMUSG00000027752Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
exosc7 / exosome component 7 / Q15024*ENSDARG0000010006027
exosc9 / exosome component 9 / Q06265* / Q9JHI7* / Exosome complex component RRP45 *ENSDARG0000000639223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR033196  Exosome complex component Rrp43


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0021693 cerebellar Purkinje cell layer structural organization IMP
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034473 U1 snRNA 3"-end processing IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0034476 U5 snRNA 3"-end processing IBA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 molecular_functionGO:0017091 AU-rich element binding IBA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000100 cerebellum cerebellum structure , abnormal
cerebellum Purkinje cell distributed , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye shape , abnormal
Show

 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
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 ZFA:0000114 heart heart quality , abnormal
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 ZFA:0001094 whole organism whole organism malformed , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
Show

 ZFA:0001479 lateral line nerve lateral line nerve myelin sheath absent , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon truncated , abnormal
motor neuron axon branchiness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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