ENSGALG00000017048


Gallus gallus

Features
Gene ID: ENSGALG00000017048
  
Biological name :EXOSC8
  
Synonyms : EXOSC8 / exosome component 8
  
Possible biological names infered from orthology : Exosome complex component RRP43 / Q96B26 / Q9D753
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 172309303
Gene end: 172318425
  
Corresponding Affymetrix probe sets: Gga.4656.1.S1_s_at (Chicken Array)   Gga.4656.2.S1_a_at (Chicken Array)   Gga.4656.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000027492
Ensembl peptide - ENSGALP00000049932
NCBI entrez gene - 100858560     See in Manteia.
RefSeq - XM_003640577
swissprot - A0A1D5PB13
swissprot - E1BUV1
Ensembl - ENSGALG00000017048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc8ENSDARG00000068755Danio rerio
 EXOSC8ENSG00000120699Homo sapiens
 Exosc8ENSMUSG00000027752Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EXOSC9 / exosome complex component RRP45 / Q06265* / Q9JHI7* / exosome component 9*ENSGALG0000001188425
EXOSC7 / exosome component 7 / Q15024* / Q9D0M0* / Exosome complex exonuclease RRP42 *ENSGALG0000003008423


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR033196  Exosome complex component Rrp43


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034473 U1 snRNA 3"-end processing IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0034476 U5 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0017091 AU-rich element binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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