ENSG00000124089


Homo sapiens

Features
Gene ID: ENSG00000124089
  
Biological name :MC3R
  
Synonyms : MC3R / melanocortin 3 receptor / P41968
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.2
Gene start: 56248732
Gene end: 56249815
  
Corresponding Affymetrix probe sets: 221442_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000243911
NCBI entrez gene - 4159     See in Manteia.
OMIM - 155540
RefSeq - NM_019888
RefSeq Peptide - NP_063941
swissprot - P41968
Ensembl - ENSG00000124089
  
Related genetic diseases (OMIM): 602025 - {Obesity, severe, susceptibility to, BMIQ9}, 602025
  607948 - {Mycobacterium tuberculosis, protection against}, 607948
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mc3rENSDARG00000021369Danio rerio
 MC3RENSGALG00000027260Gallus gallus
 Mc3rENSMUSG00000038537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MC5R / P33032 / melanocortin 5 receptorENSG0000017613659
MC4R / P32245 / melanocortin 4 receptorENSG0000016660356
MC2R / Q01718 / melanocortin 2 receptorENSG0000018523142


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001671  Melanocortin/ACTH receptor
 IPR001908  Melanocortin receptor
 IPR002122  Melanocortin 3 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0042309 homoiothermy IEA
 biological_processGO:0045475 locomotor rhythm IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055078 sodium ion homeostasis IEA
 biological_processGO:0060259 regulation of feeding behavior IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004977 melanocortin receptor activity TAS
 molecular_functionGO:0004980 melanocyte-stimulating hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042923 neuropeptide binding IMP


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115138 POMC / P01189 / proopiomelanocortin  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr