ENSMUSG00000038537


Mus musculus

Features
Gene ID: ENSMUSG00000038537
  
Biological name :Mc3r
  
Synonyms : Mc3r / Melanocortin receptor 3 / P33033
  
Possible biological names infered from orthology : melanocortin 3 receptor / P41968
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 172248492
Gene end: 172251114
  
Corresponding Affymetrix probe sets: 10478959 (MoGene1.0st)   1422237_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047358
NCBI entrez gene - 17201     See in Manteia.
MGI - MGI:96929
RefSeq - NM_008561
RefSeq Peptide - NP_032587
swissprot - P33033
swissprot - Q544G7
Ensembl - ENSMUSG00000038537
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mc3rENSDARG00000021369Danio rerio
 MC3RENSGALG00000027260Gallus gallus
 MC3RENSG00000124089Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mc5r / melanocortin 5 receptor / P33032*ENSMUSG0000000748057
Mc4r / P56450 / Melanocortin receptor 4 / P32245* / melanocortin 4 receptor*ENSMUSG0000004725955
Mc1r / Q01727 / Melanocyte-stimulating hormone receptor ENSMUSG0000007403743
Mc2r / Q64326 / melanocortin 2 receptor / Q01718*ENSMUSG0000004556942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001671  Melanocortin/ACTH receptor
 IPR001908  Melanocortin receptor
 IPR002122  Melanocortin 3 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0042309 homoiothermy IEA
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055078 sodium ion homeostasis IEA
 biological_processGO:0060259 regulation of feeding behavior IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004977 melanocortin receptor activity IEA
 molecular_functionGO:0004980 melanocyte-stimulating hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042923 neuropeptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ightm1.1(Tag)Rwhe/Igh+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp,Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

Allelic Composition: Mc3rtm1Cone/Mc3r+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Ightm1.1(Tag)Rwhe/Igh+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dll4tm2.1Vlcg/Dll4+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ightm1.1(Tag)Rwhe/Igh+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc4rtm1Lex/Mc4rtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

 MP:0005667 abnormal circulating leptin level "aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009128 decreased brown fat cell number "reduction in the number of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

Allelic Composition: Mc3rtm1Lvp/Mc3rtm1Lvp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl
Genetic Background: B6.Cg-Mc3rtm1Butl

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
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Allelic Composition: Mc4rtm1Dhu/Mc4rtm1Dhu
Genetic Background: B6.129S4-Mc4rtm1Dhu

 MP:0012320 abnormal body fat mass "aberrant fat-containing physical bulk or volume of the body" [MPD:Molly]
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Allelic Composition: Mc3rtm1Butl/Mc3rtm1Butl,Tg(Nes-cre)1Kln/0
Genetic Background: B6.Cg-Mc3rtm1Butl Tg(Nes-Cre)1Kln

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / reaction / complex






 

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