ENSMUSG00000007480


Mus musculus

Features
Gene ID: ENSMUSG00000007480
  
Biological name :Mc5r
  
Synonyms : Mc5r / melanocortin 5 receptor
  
Possible biological names infered from orthology : P33032
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 68337603
Gene end: 68339711
  
Corresponding Affymetrix probe sets: 10456513 (MoGene1.0st)   1460723_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130497
NCBI entrez gene - 17203     See in Manteia.
MGI - MGI:99420
RefSeq - NM_013596
RefSeq Peptide - NP_038624
swissprot - G3UWB6
Ensembl - ENSMUSG00000007480
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mc5raENSDARG00000031348Danio rerio
 mc5rbENSDARG00000054946Danio rerio
 MC5RENSGALG00000032087Gallus gallus
 MC5RENSG00000176136Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mc4r / P56450 / Melanocortin receptor 4 / P32245* / melanocortin 4 receptor*ENSMUSG0000004725952
Mc3r / P33033 / Melanocortin receptor 3 / P41968* / melanocortin 3 receptor*ENSMUSG0000003853750
Mc1r / Q01727 / Melanocyte-stimulating hormone receptor ENSMUSG0000007403738
Mc2r / Q64326 / melanocortin 2 receptor / Q01718*ENSMUSG0000004556936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000621  Melanocortin 5 receptor
 IPR001671  Melanocortin/ACTH receptor
 IPR001908  Melanocortin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004977 melanocortin receptor activity IEA
 molecular_functionGO:0042562 hormone binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0001348 abnormal lacrimal gland physiology 
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0013476 abnormal Harderian gland porphyrin secretion "anomaly in the production and/or release of porphyrin(s), the pigment(s) responsible for the red discoloration of ocular and/or nasal discharges in rodents; in rats, protoporhyrin IX accounts for most of the porphyrin produced and stored in the Harderian gland; in some rodents the concentration of porphyrins in the Harderian glands varies according to gender and species, and tends to be higher in females than in males" [http://ratguide.com/health/eyes/porphyrin_secretions_red_tears.php, MGI:Anna]
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Allelic Composition: Npm1tm1Ppp/Npm1tm1Ppp,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Mc5rtm1Cone/Mc5rtm1Cone
Genetic Background: B6.129S4-Mc5rtm1Cone

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / complex / reaction






 

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