ENSMUSG00000045569


Mus musculus

Features
Gene ID: ENSMUSG00000045569
  
Biological name :Mc2r
  
Synonyms : Mc2r / melanocortin 2 receptor / Q64326
  
Possible biological names infered from orthology : Q01718
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 68406907
Gene end: 68429251
  
Corresponding Affymetrix probe sets: 10459611 (MoGene1.0st)   1422926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058691
NCBI entrez gene - 17200     See in Manteia.
MGI - MGI:96928
RefSeq - NM_001301372
RefSeq - NM_008560
RefSeq - NM_001271716
RefSeq - NM_001271717
RefSeq Peptide - NP_001258645
RefSeq Peptide - NP_001258646
RefSeq Peptide - NP_001288301
RefSeq Peptide - NP_032586
swissprot - Q544P9
swissprot - Q64326
Ensembl - ENSMUSG00000045569
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mc2rENSDARG00000054949Danio rerio
 MC2RENSGALG00000035569Gallus gallus
 MC2RENSG00000185231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mc4r / P56450 / Melanocortin receptor 4 / P32245* / melanocortin 4 receptor*ENSMUSG0000004725949
Mc3r / P33033 / Melanocortin receptor 3 / P41968* / melanocortin 3 receptor*ENSMUSG0000003853746
Mc5r / melanocortin 5 receptor / P33032*ENSMUSG0000000748045
Mc1r / Q01727 / Melanocyte-stimulating hormone receptor ENSMUSG0000007403739


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001168  Adrenocorticotrophin (ACTH) receptor
 IPR001671  Melanocortin/ACTH receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004977 melanocortin receptor activity IEA
 molecular_functionGO:0004978 corticotropin receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0000640 adrenal gland hypoplasia "underdeveloped endocrine glands located above the kidney and responsible for hormone and epinephrine secretion, resulting from reduced numbers of cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0008299 adrenal cortical hyperplasia "overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc2rtm1Dgen/Mc2rtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0013565 abnormal adrenal gland capsule morphology "any structural anomaly of the thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex" [ISBN:1581124686, MGI:Anna]
Show

Allelic Composition: Kiss1rGt1Stei/Kiss1rGt1Stei
Genetic Background: involves: 129S1/SvImJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020660 Pomc / P01193 / pro-opiomelanocortin-alpha / P01189* / proopiomelanocortin*  / reaction / complex






 

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