ENSMUSG00000074037


Mus musculus

Features
Gene ID: ENSMUSG00000074037
  
Biological name :Mc1r
  
Synonyms : Mc1r / Melanocyte-stimulating hormone receptor / Q01727
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 123407107
Gene end: 123410744
  
Corresponding Affymetrix probe sets: 10576328 (MoGene1.0st)   1422069_at (Mouse Genome 430 2.0 Array)   1435393_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095929
NCBI entrez gene - 17199     See in Manteia.
MGI - MGI:99456
RefSeq - NM_008559
RefSeq Peptide - NP_032585
swissprot - A0A0B6VTJ4
swissprot - Q01727
Ensembl - ENSMUSG00000074037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mc1rENSDARG00000020237Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mc5r / melanocortin 5 receptor / P33032*ENSMUSG0000000748045
Mc4r / P56450 / Melanocortin receptor 4 / P32245* / melanocortin 4 receptor*ENSMUSG0000004725945
Mc3r / P33033 / Melanocortin receptor 3 / P41968* / melanocortin 3 receptor*ENSMUSG0000003853744
Mc2r / Q64326 / melanocortin 2 receptor / Q01718*ENSMUSG0000004556936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000761  Melanocyte-stimulating hormone receptor
 IPR001671  Melanocortin/ACTH receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0010739 positive regulation of protein kinase A signaling IDA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production ISO
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042438 melanin biosynthetic process IMP
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0070914 UV-damage excision repair ISO
 biological_processGO:0090037 positive regulation of protein kinase C signaling IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004977 melanocortin receptor activity IDA
 molecular_functionGO:0004980 melanocyte-stimulating hormone receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts20bt/Adamts20bt,Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha * DBA

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Mc1rE-so/Mc1rE-so
Genetic Background: C3H

Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Mc1re/Mc1re,Xpctm1Brd/Xpctm1Brd,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Mc1re/Mc1re,Xpctm1Brd/Xpctm1Brd,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001224 abnormal keratinocyte apoptosis "aberrant programmed cell death of keratin producing cells of the epidermis" [J:64948]
Show

Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mc1re/Mc1re,Pepddal/Pepddal
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001968 abnormal touch/ nociception "change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ryr2tm1Slh/Ryr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Mc1re/Mc1re
Genetic Background: C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Mc1re/Mc1re,Xpctm1Brd/Xpctm1Brd,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: A/A,Mc1rE-tob/Mc1rE-tob
Genetic Background: M. m. domesticus poschiavinus

Allelic Composition: Mc1rtaw/Mc1rtaw
Genetic Background: M. m. molossinus

Allelic Composition: Mc1rm1Btlr/Mc1rm1Btlr
Genetic Background: C57BL/6J-Mc1rm1Btlr

Allelic Composition: A/A,Mc1rE-tob/Mc1r+
Genetic Background: M. m. domesticus poschiavinus

Allelic Composition: Mc1rtm1.1(KOMP)Vlcg/Mc1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Mc1rtm1.1(KOMP)Vlcg/Ucd

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mc1rtaw/Mc1rtaw
Genetic Background: M. m. molossinus

Allelic Composition: Mc1rE-so/Mc1rE-so
Genetic Background: C3H

Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

 MP:0002671 belted "the appearance of a stripe of white fur around the circumference of the abdomen" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbs/Ednrbs,Mc1re/Mc1re
Genetic Background: Not Specified

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbs/Ednrbs,Mc1re/Mc1re
Genetic Background: Not Specified

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Mc1re/Mc1re
Genetic Background: C57BL/6Ha

Allelic Composition: Ednrbs/Ednrbs,Mc1re/Mc1re
Genetic Background: Not Specified

Allelic Composition: Adamts20bt/Adamts20bt,Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha * DBA

Allelic Composition: Mc1rtaw/Mc1rtaw
Genetic Background: M. m. molossinus

Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

Allelic Composition: Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha

Allelic Composition: Ay-Jkn/A,Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha * C57BL/6N

Allelic Composition: Ay-Jkn/A,Mc1re/Mc1re,Tg(MC1R)1Jkn/0
Genetic Background: involves: C57BL/6Ha * C57BL/6N

Allelic Composition: a/A,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: Mc1re/Mc1re,Pepddal/Pepddal
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Mc1rmpc59H/Mc1rmpc59H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc1re/Mc1re,Xpctm1Brd/Xpctm1Brd,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004270 analgesia "inability to sense pain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc1re/Mc1re
Genetic Background: C57BL/6

 MP:0004382 abnormal hair follicle melanogenesis "failure of or anomaly in the biosynthetic pathway of melanin formation in hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc1re/Mc1re
Genetic Background: C57BL/6Ha

 MP:0005077 abnormal melanogenesis "failure of or anomaly in the biosynthetic pathway of melanin formation in cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
Show

Allelic Composition: Apctm1Hsa/Apc+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mc1re/Mc1re,Tg(KRT14-Kitl)1Takk/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: A/A,Mc1rE-tob/Mc1rE-tob
Genetic Background: M. m. domesticus poschiavinus

Allelic Composition: Mc1rE-so/Mc1rE-so
Genetic Background: C3H

Allelic Composition: Mc1rE-so/Mc1r+
Genetic Background: C3H

Allelic Composition: Mc1rE-so3J/Mc1rE-so3J
Genetic Background: CBA/J

Allelic Composition: A/A,Mc1rE-tob/Mc1r+
Genetic Background: M. m. domesticus poschiavinus

Allelic Composition: Mc1rE-So4J/Mc1r+
Genetic Background: B6.Cg-Mc1rE-So4J/GrsrJ

 MP:0006370 abnormal phaeomelanin content "anomaly in the amount or distribution of yellow pigment in the hair" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc1re/Mc1re
Genetic Background: involves: C57BL/6Ha

Allelic Composition: a/A,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

Allelic Composition: a/a,Mc1re/Mc1re,Pomctm1Sora/Pomctm1Sora,Tg(MC1R)1Jkn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6Ha

 MP:0009928 abnormal pinna hair pigmentation "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased or increased in hair located behind the ears when compared to control animal pigmentation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitlSl-34H/Kitl+
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Mc1rE-So4J/Mc1r+
Genetic Background: B6.Cg-Mc1rE-So4J/GrsrJ

 MP:0009933 abnormal tail hair pigmentation "an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mc1rE-So4J/Mc1r+
Genetic Background: B6.Cg-Mc1rE-So4J/GrsrJ

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
Show

Allelic Composition: Mc1rtaw/Mc1rtaw
Genetic Background: M. m. molossinus

 MP:0011279 decreased ear pigmentation "visually detectable dilution of pigment present in the outer ear" [MGI:csmith]
Show

Allelic Composition: Mc1rtaw/Mc1rtaw
Genetic Background: M. m. molossinus

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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