ENSG00000124831


Homo sapiens

Features
Gene ID: ENSG00000124831
  
Biological name :LRRFIP1
  
Synonyms : LRR binding FLII interacting protein 1 / LRRFIP1 / Q32MZ4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 237627576
Gene end: 237813682
  
Corresponding Affymetrix probe sets: 201861_s_at (Human Genome U133 Plus 2.0 Array)   201862_s_at (Human Genome U133 Plus 2.0 Array)   211452_x_at (Human Genome U133 Plus 2.0 Array)   215375_x_at (Human Genome U133 Plus 2.0 Array)   219957_at (Human Genome U133 Plus 2.0 Array)   223492_s_at (Human Genome U133 Plus 2.0 Array)   227391_x_at (Human Genome U133 Plus 2.0 Array)   227513_s_at (Human Genome U133 Plus 2.0 Array)   238534_at (Human Genome U133 Plus 2.0 Array)   238840_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409431
Ensembl peptide - ENSP00000289175
Ensembl peptide - ENSP00000310109
Ensembl peptide - ENSP00000375857
Ensembl peptide - ENSP00000244815
NCBI entrez gene - 9208     See in Manteia.
OMIM - 603256
RefSeq - XM_017005262
RefSeq - XM_017005255
RefSeq - XM_017005256
RefSeq - XM_017005257
RefSeq - XM_017005258
RefSeq - XM_017005259
RefSeq - XM_017005260
RefSeq - XM_017005261
RefSeq - NM_001137550
RefSeq - NM_001137552
RefSeq - NM_001137553
RefSeq - NM_004735
RefSeq - XM_017005253
RefSeq - XM_017005254
RefSeq Peptide - NP_004726
RefSeq Peptide - NP_001131022
RefSeq Peptide - NP_001131024
RefSeq Peptide - NP_001131025
swissprot - Q32MZ4
swissprot - C9JTC6
swissprot - A0A0F7NGI8
Ensembl - ENSG00000124831
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrrfip1aENSDARG00000030012Danio rerio
 lrrfip1bENSDARG00000095170Danio rerio
 ENSGALG00000003862Gallus gallus
 Q3UZ39ENSMUSG00000026305Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y608 / LRRFIP2 / LRR binding FLII interacting protein 2ENSG0000009316719


Protein motifs (from Interpro)
Interpro ID Name
 IPR019139  Leucine-rich repeat flightless-interacting protein 1/2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0032481 positive regulation of type I interferon production TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated NAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Signaling by cytosolic FGFR1 fusion mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Signaling by FGFR1 in disease


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124831 Q32MZ4 / LRRFIP1 / LRR binding FLII interacting protein 1  / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex






 

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