ENSG00000125630


Homo sapiens

Features
Gene ID: ENSG00000125630
  
Biological name :POLR1B
  
Synonyms : POLR1B / Q9H9Y6 / RNA polymerase I subunit B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.1
Gene start: 112541915
Gene end: 112577150
  
Corresponding Affymetrix probe sets: 1557331_at (Human Genome U133 Plus 2.0 Array)   220113_x_at (Human Genome U133 Plus 2.0 Array)   223403_s_at (Human Genome U133 Plus 2.0 Array)   233341_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437914
Ensembl peptide - ENSP00000388577
Ensembl peptide - ENSP00000387143
Ensembl peptide - ENSP00000334589
Ensembl peptide - ENSP00000263331
Ensembl peptide - ENSP00000405358
Ensembl peptide - ENSP00000415754
Ensembl peptide - ENSP00000444136
Ensembl peptide - ENSP00000390274
Ensembl peptide - ENSP00000390973
Ensembl peptide - ENSP00000394408
Ensembl peptide - ENSP00000403094
NCBI entrez gene - 84172     See in Manteia.
OMIM - 602000
RefSeq - NM_019014
RefSeq - NM_001137604
RefSeq - NM_001282772
RefSeq - NM_001282774
RefSeq - NM_001282776
RefSeq - NM_001282777
RefSeq - NM_001282779
RefSeq Peptide - NP_001131076
RefSeq Peptide - NP_061887
RefSeq Peptide - NP_001269708
RefSeq Peptide - NP_001269706
RefSeq Peptide - NP_001269705
RefSeq Peptide - NP_001269703
RefSeq Peptide - NP_001269701
swissprot - Q9H9Y6
swissprot - C9JJG2
swissprot - C9JS83
swissprot - F8WAK7
swissprot - F8WBB9
swissprot - F8WCS3
swissprot - F8WDS4
swissprot - H7C0D9
Ensembl - ENSG00000125630
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr1bENSDARG00000077469Danio rerio
 POLR1BENSGALG00000032273Gallus gallus
 P70700ENSMUSG00000027395Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007120  DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
 IPR007121  RNA polymerase, beta subunit, conserved site
 IPR007641  RNA polymerase Rpb2, domain 7
 IPR007642  RNA polymerase Rpb2, domain 2
 IPR007644  RNA polymerase, beta subunit, protrusion
 IPR007645  RNA polymerase Rpb2, domain 3
 IPR009674  DNA-directed RNA polymerase I subunit RPA2, domain 4
 IPR015712  DNA-directed RNA polymerase, subunit 2
 IPR037033  DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
 IPR037034  RNA polymerase Rpb2, domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter TAS
 biological_processGO:0006362 transcription elongation from RNA polymerase I promoter TAS
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0009303 rRNA transcription IEA
 biological_processGO:0017126 nucleologenesis IEA
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005736 DNA-directed RNA polymerase I complex IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0001054 RNA polymerase I activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0032549 ribonucleoside binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase I Transcription Termination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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