ENSMUSG00000027395


Mus musculus

Features
Gene ID: ENSMUSG00000027395
  
Biological name :Polr1b
  
Synonyms : DNA-directed RNA polymerase I subunit RPA2 / P70700 / Polr1b
  
Possible biological names infered from orthology : Q9H9Y6 / RNA polymerase I subunit B
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 129100995
Gene end: 129126594
  
Corresponding Affymetrix probe sets: 10475965 (MoGene1.0st)   1416126_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099494
Ensembl peptide - ENSMUSP00000028874
NCBI entrez gene - 20017     See in Manteia.
MGI - MGI:108014
RefSeq - NM_009086
RefSeq - XM_006499025
RefSeq Peptide - NP_033112
swissprot - A2AP84
swissprot - P70700
Ensembl - ENSMUSG00000027395
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr1bENSDARG00000077469Danio rerio
 POLR1BENSGALG00000032273Gallus gallus
 POLR1BENSG00000125630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007120  DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
 IPR007121  RNA polymerase, beta subunit, conserved site
 IPR007641  RNA polymerase Rpb2, domain 7
 IPR007642  RNA polymerase Rpb2, domain 2
 IPR007644  RNA polymerase, beta subunit, protrusion
 IPR007645  RNA polymerase Rpb2, domain 3
 IPR009674  DNA-directed RNA polymerase I subunit RPA2, domain 4
 IPR015712  DNA-directed RNA polymerase, subunit 2
 IPR037033  DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
 IPR037034  RNA polymerase Rpb2, domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006360 transcription by RNA polymerase I IEA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0009303 rRNA transcription IMP
 biological_processGO:0017126 nucleologenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005736 DNA-directed RNA polymerase I complex IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0001054 RNA polymerase I activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0032549 ribonucleoside binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase I Transcription Termination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008830 abnormal nucleolus morphology "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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