ENSG00000128050


Homo sapiens

Features
Gene ID: ENSG00000128050
  
Biological name :PAICS
  
Synonyms : P22234 / PAICS / phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q12
Gene start: 56435741
Gene end: 56464579
  
Corresponding Affymetrix probe sets: 201013_s_at (Human Genome U133 Plus 2.0 Array)   201014_s_at (Human Genome U133 Plus 2.0 Array)   214664_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264221
Ensembl peptide - ENSP00000424907
Ensembl peptide - ENSP00000424053
Ensembl peptide - ENSP00000421096
Ensembl peptide - ENSP00000382595
NCBI entrez gene - 10606     See in Manteia.
OMIM - 172439
RefSeq - XM_011534366
RefSeq - NM_001079524
RefSeq - NM_001079525
RefSeq - NM_006452
RefSeq Peptide - NP_001072993
RefSeq Peptide - NP_001072992
RefSeq Peptide - NP_006443
swissprot - P22234
swissprot - A0A024RD93
swissprot - E9PBS1
swissprot - D6RF62
Ensembl - ENSG00000128050
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 paicsENSDARG00000033539Danio rerio
 PAICSENSGALG00000013726Gallus gallus
 PaicsENSMUSG00000029247Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000031  PurE domain
 IPR018236  SAICAR synthetase, conserved site
 IPR028923  SAICAR synthetase/ADE2, N-terminal
 IPR033626  Class II PurE
 IPR035893  PurE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006189 "de novo" IMP biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process TAS
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004638 phosphoribosylaminoimidazole carboxylase activity TAS
 molecular_functionGO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000128050 PAICS / P22234 / phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase  / complex






 

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