ENSG00000131981


Homo sapiens

Features
Gene ID: ENSG00000131981
  
Biological name :LGALS3
  
Synonyms : galectin 3 / LGALS3 / P17931
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q22.3
Gene start: 55124110
Gene end: 55145413
  
Corresponding Affymetrix probe sets: 1557197_a_at (Human Genome U133 Plus 2.0 Array)   208949_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451526
Ensembl peptide - ENSP00000254301
Ensembl peptide - ENSP00000451381
NCBI entrez gene - 3958     See in Manteia.
OMIM - 153619
RefSeq - XM_011536759
RefSeq - NM_001177388
RefSeq - NM_002306
RefSeq Peptide - NP_002297
swissprot - P17931
swissprot - A0A024R693
swissprot - G3V3R6
swissprot - G3V407
Ensembl - ENSG00000131981
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGALS3ENSGALG00000012173Gallus gallus
 Lgals3ENSMUSG00000050335Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGALS4 / P56470 / galectin 4ENSG0000017174732
Q6DKI2 / LGALS9C / galectin 9CENSG0000017191631
Q3B8N2 / LGALS9B / galectin 9BENSG0000017029831
LGALS9 / O00182 / galectin 9ENSG0000016896131
LGALS8 / O00214 / galectin 8ENSG0000011697728
Q96DT0 / LGALS12 / galectin 12ENSG0000013331720
LGALSL / Q3ZCW2 / galectin likeENSG0000011986218
P47929 / LGALS7B / galectin 7BENSG0000017893417
LGALS7 / P47929 / galectin 7ENSG0000020507617
A4D1Z8 / GRIFIN / galectin-related inter-fiber proteinENSG0000027557214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015534  Galectin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002548 monocyte chemotaxis IDA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0030855 epithelial cell differentiation IEP
 biological_processGO:0042129 regulation of T cell proliferation IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045637 regulation of myeloid cell differentiation TAS
 biological_processGO:0045806 negative regulation of endocytosis IDA
 biological_processGO:0048245 eosinophil chemotaxis IDA
 biological_processGO:0048246 macrophage chemotaxis IDA
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway ISS
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0070232 regulation of T cell apoptotic process IDA
 biological_processGO:0071674 mononuclear cell migration IDA
 biological_processGO:0071677 positive regulation of mononuclear cell migration IDA
 biological_processGO:0090280 positive regulation of calcium ion import IDA
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:2000521 negative regulation of immunological synapse formation ISS
 biological_processGO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISS
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019863 IgE binding IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0043236 laminin binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX2 regulates genes involved in differentiation of myeloid cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr