ENSMUSG00000050335


Mus musculus

Features
Gene ID: ENSMUSG00000050335
  
Biological name :Lgals3
  
Synonyms : galectin 3 / Lgals3
  
Possible biological names infered from orthology : P17931
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 47367751
Gene end: 47386160
  
Corresponding Affymetrix probe sets: 10414360 (MoGene1.0st)   1426808_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118660
Ensembl peptide - ENSMUSP00000154551
Ensembl peptide - ENSMUSP00000119275
Ensembl peptide - ENSMUSP00000114177
Ensembl peptide - ENSMUSP00000114350
Ensembl peptide - ENSMUSP00000118169
NCBI entrez gene - 16854     See in Manteia.
MGI - MGI:96778
RefSeq - NM_001145953
RefSeq - NM_010705
RefSeq Peptide - NP_001139425
RefSeq Peptide - NP_034835
swissprot - Q8C253
swissprot - D3YVT4
swissprot - D3YZJ2
Ensembl - ENSMUSG00000050335
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGALS3ENSGALG00000012173Gallus gallus
 LGALS3ENSG00000131981Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lgals9 / O08573 / Galectin-9 / Q6DKI2* / O00182* / Q3B8N2* / LGALS9B* / LGALS9C* / galectin 9B* / galectin 9C*ENSMUSG0000000112330
Lgals4 / Q8K419 / Galectin-4 / P56470*ENSMUSG0000005396429
Lgals8 / Q9JL15 / Galectin-8 / O00214*ENSMUSG0000005755425
Q91VD1 / Lgals12 / Mus musculus lectin, galactose binding, soluble 12 (Lgals12), transcript variant 2, mRNA. / Q96DT0* / galectin 12*ENSMUSG0000002497220
Lgalsl / Q8VED9 / Galectin-related protein / Q3ZCW2* / galectin like*ENSMUSG0000004236316
Lgals7 / P47929* / LGALS7B* / galectin 7* / galectin 7B*ENSMUSG0000005352216
Gm5065 / Q7TPX9 / Galectin-related protein B / LGALSL* / Q3ZCW2* / galectin like*ENSMUSG0000004839815
Grifin / Q9D1U0 / A4D1Z8* / galectin-related inter-fiber protein*ENSMUSG0000003658614


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015534  Galectin-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0042129 regulation of T cell proliferation IEA
 biological_processGO:0045806 negative regulation of endocytosis IEA
 biological_processGO:0048245 eosinophil chemotaxis IEA
 biological_processGO:0048246 macrophage chemotaxis IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0070232 regulation of T cell apoptotic process IEA
 biological_processGO:0071674 mononuclear cell migration IEA
 biological_processGO:0071677 positive regulation of mononuclear cell migration IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0019863 IgE binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0043236 laminin binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Cys1cpk/Cys1cpk,Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cys1cpk/Cys1cpk,Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: B6.Cg-Cys1cpk Lgals3tm1Ftl

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0001358 aggression to inanimate objects "a domineering, assault posture and/or hostile physical action toward inanimate objects" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdh23v/Cdh23+,Myo7a4626SB/Myo7a+
Genetic Background: involves: BALB/cRl * 47BS/Rl * CBA/Ca

 MP:0002436 abnormal cytotoxic T cell morphology/development "anomalous structure, formation, or numbers of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0002620 abnormal monocyte morphology "anomalous structure, number, or development of the white blood cells that are precursors to macrophages" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cys1cpk/Cys1cpk,Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cys1cpk/Cys1cpk,Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: B6.Cg-Cys1cpk Lgals3tm1Ftl

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cys1cpk/Cys1cpk,Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmdmdx/Y
Genetic Background: C57BL/10ScSn-Dmdmdx/J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Pik3catm1Bvan/Pik3ca+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014045 Mallory bodies "stereotypical manifestations of hepatocyte injury that present as cytoplasmic inclusion bodies consisting of intermediate filament components (e.g., modified cytokeratins, chaperones and protein degradation machinery)" [PMID:17531973, PMID:7927209]
Show

Allelic Composition: Fignfi/Fignfi,Vsx2or/Vsx2or
Genetic Background: involves: C57BL/Gr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr