ENSMUSG00000024972


Mus musculus

Features
Gene ID: ENSMUSG00000024972
  
Biological name :Lgals12
  
Synonyms : Lgals12 / Mus musculus lectin, galactose binding, soluble 12 (Lgals12), transcript variant 2, mRNA. / Q91VD1
  
Possible biological names infered from orthology : galectin 12 / Q96DT0
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 7596660
Gene end: 7607193
  
Corresponding Affymetrix probe sets: 10465701 (MoGene1.0st)   1417686_at (Mouse Genome 430 2.0 Array)   1417687_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078824
Ensembl peptide - ENSMUSP00000097318
Ensembl peptide - ENSMUSP00000124610
NCBI entrez gene - 56072     See in Manteia.
MGI - MGI:1929094
RefSeq - XM_006527221
RefSeq - NM_001356574
RefSeq - NM_019516
RefSeq - XM_006527219
RefSeq Peptide - NP_001343503
RefSeq Peptide - NP_062389
swissprot - Q91VD1
Ensembl - ENSMUSG00000024972
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q96DT0ENSG00000133317Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lgals4 / Q8K419 / Galectin-4 / P56470*ENSMUSG0000005396432
Lgals9 / O08573 / Galectin-9 / Q6DKI2* / O00182* / Q3B8N2* / LGALS9B* / LGALS9C* / galectin 9B* / galectin 9C*ENSMUSG0000000112330
Lgals8 / Q9JL15 / Galectin-8 / O00214*ENSMUSG0000005755427
Lgals3 / galectin 3 / P17931*ENSMUSG0000005033517
Lgalsl / Q8VED9 / Galectin-related protein / Q3ZCW2* / galectin like*ENSMUSG0000004236314
Gm5065 / Q7TPX9 / Galectin-related protein B / LGALSL* / Q3ZCW2* / galectin like*ENSMUSG0000004839811
Lgals7 / P47929* / LGALS7B* / galectin 7* / galectin 7B*ENSMUSG0000005352211
Grifin / Q9D1U0 / A4D1Z8* / galectin-related inter-fiber protein*ENSMUSG000000365868


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR030649  Galectin-12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0045598 regulation of fat cell differentiation IEA
 biological_processGO:0050994 regulation of lipid catabolic process IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0030395 lactose binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000679 increased percent water in carcass "more than the normal total amount of water retained in the body measured post mortem" [il:Ira Lu, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003441 increased glycerol level "higher than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: B6.129-Lgals12tm1Ftl

 MP:0010358 abnormal free fatty acids level "any anomaly in the concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: B6.129-Lgals12tm1Ftl

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
Show

Allelic Composition: Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: B6.129-Lgals12tm1Ftl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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