ENSMUSG00000001123


Mus musculus

Features
Gene ID: ENSMUSG00000001123
  
Biological name :Lgals9
  
Synonyms : Galectin-9 / Lgals9 / O08573
  
Possible biological names infered from orthology : galectin 9B / galectin 9C / LGALS9B / LGALS9C / O00182 / Q3B8N2 / Q6DKI2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 78962974
Gene end: 78984946
  
Corresponding Affymetrix probe sets: 10388902 (MoGene1.0st)   1421217_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103904
Ensembl peptide - ENSMUSP00000072764
Ensembl peptide - ENSMUSP00000103903
NCBI entrez gene - 16859     See in Manteia.
MGI - MGI:109496
RefSeq - NM_010708
RefSeq - NM_001159301
RefSeq Peptide - NP_001152773
RefSeq Peptide - NP_034838
swissprot - O08573
swissprot - G3X9T7
swissprot - B1AQR8
Ensembl - ENSMUSG00000001123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgals9l1ENSDARG00000025903Danio rerio
 lgals9l3ENSDARG00000041060Danio rerio
 lgals9l4ENSDARG00000069058Danio rerio
 lgals9l5ENSDARG00000087311Danio rerio
 lgals9l6ENSDARG00000093059Danio rerio
 LGALS9ENSG00000168961Homo sapiens
 Q3B8N2ENSG00000170298Homo sapiens
 Q6DKI2ENSG00000171916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lgals4 / Q8K419 / Galectin-4 / P56470*ENSMUSG0000005396440
Lgals8 / Q9JL15 / Galectin-8 / O00214*ENSMUSG0000005755433
Q91VD1 / Lgals12 / Mus musculus lectin, galactose binding, soluble 12 (Lgals12), transcript variant 2, mRNA. / Q96DT0* / galectin 12*ENSMUSG0000002497227
Lgals3 / galectin 3 / P17931*ENSMUSG0000005033523
Lgalsl / Q8VED9 / Galectin-related protein / Q3ZCW2* / galectin like*ENSMUSG0000004236313
Grifin / Q9D1U0 / A4D1Z8* / galectin-related inter-fiber protein*ENSMUSG0000003658612
Lgals7 / P47929* / LGALS7B* / galectin 7* / galectin 7B*ENSMUSG0000005352212
Gm5065 / Q7TPX9 / Galectin-related protein B / LGALSL* / Q3ZCW2* / galectin like*ENSMUSG0000004839812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISA
 biological_processGO:0007565 female pregnancy IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0032732 positive regulation of interleukin-1 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032815 negative regulation of natural killer cell activation IMP
 biological_processGO:0032823 regulation of natural killer cell differentiation IMP
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0043322 negative regulation of natural killer cell degranulation IMP
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045185 maintenance of protein location IDA
 biological_processGO:0045591 positive regulation of regulatory T cell differentiation IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0051353 positive regulation of oxidoreductase activity IDA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1900426 positive regulation of defense response to bacterium IMP
 biological_processGO:1902714 negative regulation of interferon-gamma secretion IDA
 biological_processGO:2000406 positive regulation of T cell migration IDA
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IMP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 biological_processGO:2001181 positive regulation of interleukin-10 secretion IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016936 galactoside binding ISA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr,Dlx6tm1Jlr/Dlx6tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0020155 enhanced humoral immune response "enhanced response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020399 Havcr2 / Q8VIM0 / Hepatitis A virus cellular receptor 2 homolog / Q8TDQ0* / hepatitis A virus cellular receptor 2*  / reaction / complex






 

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