ENSG00000168961


Homo sapiens

Features
Gene ID: ENSG00000168961
  
Biological name :LGALS9
  
Synonyms : galectin 9 / LGALS9 / O00182
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 27629798
Gene end: 27649560
  
Corresponding Affymetrix probe sets: 203236_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463125
Ensembl peptide - ENSP00000462668
Ensembl peptide - ENSP00000464581
Ensembl peptide - ENSP00000467505
Ensembl peptide - ENSP00000306228
Ensembl peptide - ENSP00000318214
Ensembl peptide - ENSP00000378856
Ensembl peptide - ENSP00000462359
Ensembl peptide - ENSP00000462382
NCBI entrez gene - 3965     See in Manteia.
OMIM - 601879
RefSeq - XM_017024623
RefSeq - NM_002308
RefSeq - NM_009587
RefSeq - XM_006721892
RefSeq - XM_006721893
RefSeq - XM_006721894
RefSeq - XM_006721895
RefSeq Peptide - NP_001317092
RefSeq Peptide - NP_002299
RefSeq Peptide - NP_033665
swissprot - J3KS82
swissprot - J3KSA0
swissprot - J3QKK6
swissprot - J3QS92
swissprot - O00182
swissprot - K7EPS0
swissprot - A0A024QZ02
swissprot - A0A024QZ55
Ensembl - ENSG00000168961
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgals9l1ENSDARG00000025903Danio rerio
 lgals9l3ENSDARG00000041060Danio rerio
 lgals9l4ENSDARG00000069058Danio rerio
 lgals9l5ENSDARG00000087311Danio rerio
 lgals9l6ENSDARG00000093059Danio rerio
 Lgals9ENSMUSG00000001123Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3B8N2 / LGALS9B / galectin 9BENSG0000017029895
Q6DKI2 / LGALS9C / galectin 9CENSG0000017191694
LGALS4 / P56470 / galectin 4ENSG0000017174736
LGALS8 / O00214 / galectin 8ENSG0000011697731
Q96DT0 / LGALS12 / galectin 12ENSG0000013331726
LGALS3 / P17931 / galectin 3ENSG0000013198122
LGALSL / Q3ZCW2 / galectin likeENSG0000011986214
P47929 / LGALS7B / galectin 7BENSG0000017893414
LGALS7 / P47929 / galectin 7ENSG0000020507614
A4D1Z8 / GRIFIN / galectin-related inter-fiber proteinENSG0000027557211


Protein motifs (from Interpro)
Interpro ID Name
 IPR001079  Galectin, carbohydrate recognition domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002519 natural killer cell tolerance induction IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007565 female pregnancy IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032682 negative regulation of chemokine production IMP
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response IDA
 biological_processGO:0038066 p38MAPK cascade IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043305 negative regulation of mast cell degranulation IMP
 biological_processGO:0045953 negative regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IMP
 biological_processGO:0046598 positive regulation of viral entry into host cell IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IDA
 biological_processGO:0070241 positive regulation of activated T cell autonomous cell death IDA
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070555 response to interleukin-1 IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071636 positive regulation of transforming growth factor beta production IDA
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1902715 positive regulation of interferon-gamma secretion IDA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IMP
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IMP
 biological_processGO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
 biological_processGO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
 biological_processGO:2000667 positive regulation of interleukin-13 secretion IDA
 biological_processGO:2000670 positive regulation of dendritic cell apoptotic process IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 biological_processGO:2001181 positive regulation of interleukin-10 secretion IDA
 biological_processGO:2001184 positive regulation of interleukin-12 secretion IMP
 biological_processGO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
 biological_processGO:2001200 positive regulation of dendritic cell differentiation IMP
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005534 galactose binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0048030 disaccharide binding IMP


Pathways (from Reactome)
Pathway description
Interleukin-2 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135077 HAVCR2 / Q8TDQ0 / hepatitis A virus cellular receptor 2  / reaction / complex






 

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