ENSG00000135077


Homo sapiens

Features
Gene ID: ENSG00000135077
  
Biological name :HAVCR2
  
Synonyms : HAVCR2 / hepatitis A virus cellular receptor 2 / Q8TDQ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q33.3
Gene start: 157085832
Gene end: 157142869
  
Corresponding Affymetrix probe sets: 1554285_at (Human Genome U133 Plus 2.0 Array)   1555628_a_at (Human Genome U133 Plus 2.0 Array)   1555629_at (Human Genome U133 Plus 2.0 Array)   235458_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312002
Ensembl peptide - ENSP00000430873
Ensembl peptide - ENSP00000430328
NCBI entrez gene - 84868     See in Manteia.
OMIM - 606652
RefSeq - NM_032782
RefSeq Peptide - NP_116171
swissprot - E5RHN3
swissprot - E5RFR4
swissprot - Q8TDQ0
Ensembl - ENSG00000135077
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timd4ENSDARG00000077257Danio rerio
 HAVCR1ENSGALG00000017362Gallus gallus
 Havcr2ENSMUSG00000020399Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HAVCR1 / Q96D42 / hepatitis A virus cellular receptor 1ENSG0000011324923
TIMD4 / Q96H15 / T cell immunoglobulin and mucin domain containing 4ENSG0000014585022


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002519 natural killer cell tolerance induction IMP
 biological_processGO:0002652 regulation of tolerance induction dependent upon immune response IEA
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IEA
 biological_processGO:0002838 negative regulation of immune response to tumor cell IEA
 biological_processGO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030886 negative regulation of myeloid dendritic cell activation IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032480 negative regulation of type I interferon production IEA
 biological_processGO:0032687 negative regulation of interferon-alpha production IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0032712 negative regulation of interleukin-3 production IDA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032732 positive regulation of interleukin-1 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032815 negative regulation of natural killer cell activation IEA
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034154 toll-like receptor 7 signaling pathway IEA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071656 negative regulation of granulocyte colony-stimulating factor production IDA
 biological_processGO:1900425 negative regulation of defense response to bacterium IEA
 biological_processGO:1900426 positive regulation of defense response to bacterium IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:2000521 negative regulation of immunological synapse formation IEA
 biological_processGO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-2 family signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168961 LGALS9 / O00182 / galectin 9  / reaction / complex






 

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