ENSG00000133119


Homo sapiens

Features
Gene ID: ENSG00000133119
  
Biological name :RFC3
  
Synonyms : P40938 / replication factor C subunit 3 / RFC3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q13.2
Gene start: 33818049
Gene end: 33966558
  
Corresponding Affymetrix probe sets: 204127_at (Human Genome U133 Plus 2.0 Array)   204128_s_at (Human Genome U133 Plus 2.0 Array)   231119_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401001
Ensembl peptide - ENSP00000484747
Ensembl peptide - ENSP00000369411
NCBI entrez gene - 5983     See in Manteia.
OMIM - 600405
RefSeq - XM_017020683
RefSeq - XM_011535174
RefSeq - XM_011535175
RefSeq - XM_017020680
RefSeq - XM_017020681
RefSeq - XM_017020682
RefSeq - NM_002915
RefSeq - NM_181558
RefSeq - XM_011535172
RefSeq - XM_011535173
RefSeq Peptide - NP_002906
RefSeq Peptide - NP_853536
swissprot - A0A087X270
swissprot - P40938
swissprot - A0A024RDQ8
Ensembl - ENSG00000133119
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfc3ENSDARG00000055969Danio rerio
 RFC3ENSGALG00000017064Gallus gallus
 Rfc3ENSMUSG00000033970Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR008921  DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000731 DNA synthesis involved in DNA repair TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006271 DNA strand elongation involved in DNA replication TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0042276 error-prone translesion synthesis TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0046683 response to organophosphorus IEP
 biological_processGO:0070987 error-free translesion synthesis TAS
 biological_processGO:1900264 positive regulation of DNA-directed DNA polymerase activity IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005663 DNA replication factor C complex TAS
 cellular_componentGO:0031390 Ctf18 RFC-like complex IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003689 DNA clamp loader activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0043142 single-stranded DNA-dependent ATPase activity IDA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Activation of ATR in response to replication stress
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Phosphorylation
Polymerase switching
G2/M DNA damage checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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