ENSG00000133997


Homo sapiens

Features
Gene ID: ENSG00000133997
  
Biological name :MED6
  
Synonyms : MED6 / mediator complex subunit 6 / O75586
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.2
Gene start: 70581257
Gene end: 70600690
  
Corresponding Affymetrix probe sets: 207078_at (Human Genome U133 Plus 2.0 Array)   207079_s_at (Human Genome U133 Plus 2.0 Array)   210104_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000256379
Ensembl peptide - ENSP00000413343
Ensembl peptide - ENSP00000451684
Ensembl peptide - ENSP00000481920
Ensembl peptide - ENSP00000394502
NCBI entrez gene - 10001     See in Manteia.
OMIM - 602984
RefSeq - NM_001284209
RefSeq - NM_001284210
RefSeq - NM_001284211
RefSeq - NM_005466
RefSeq Peptide - NP_001271139
RefSeq Peptide - NP_001271138
RefSeq Peptide - NP_005457
RefSeq Peptide - NP_001271140
swissprot - O75586
swissprot - G3V4A5
swissprot - A0A087WYL7
Ensembl - ENSG00000133997
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med6ENSDARG00000034734Danio rerio
 MED6ENSGALG00000029743Gallus gallus
 Med6ENSMUSG00000002679Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007018  Mediator complex, subunit Med6
 IPR016820  Mediator complex, subunit Med6, metazoa/plant


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IBA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016592 mediator complex IEA
 cellular_componentGO:0070847 core mediator complex IBA
 molecular_functionGO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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