ENSG00000135346


Homo sapiens

Features
Gene ID: ENSG00000135346
  
Biological name :CGA
  
Synonyms : CGA / glycoprotein hormones, alpha polypeptide / P01215
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q14.3
Gene start: 87085498
Gene end: 87095406
  
Corresponding Affymetrix probe sets: 204637_at (Human Genome U133 Plus 2.0 Array)   233615_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358595
Ensembl peptide - ENSP00000487300
Ensembl peptide - ENSP00000486666
Ensembl peptide - ENSP00000486024
Ensembl peptide - ENSP00000482232
NCBI entrez gene - 1081     See in Manteia.
OMIM - 118850
RefSeq - NM_001252383
RefSeq - NM_000735
RefSeq Peptide - NP_000726
RefSeq Peptide - NP_001239312
swissprot - A0A0R4J2F0
swissprot - Q6I9S8
swissprot - A0A0D9SGA7
swissprot - A0A0D9SFJ6
swissprot - A0A087WYZ4
swissprot - P01215
Ensembl - ENSG00000135346
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01003476.1ENSDARG00000103345Danio rerio
 cgaENSDARG00000040479Danio rerio
 CGAENSGALG00000015824Gallus gallus
 CgaENSMUSG00000028298Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000476  Glycoprotein hormone alpha chain
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006590 thyroid hormone generation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008284 positive regulation of cell proliferation NAS
 biological_processGO:0008406 gonad development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016486 peptide hormone processing TAS
 biological_processGO:0030335 positive regulation of cell migration NAS
 biological_processGO:0030878 thyroid gland development IEA
 biological_processGO:0032275 luteinizing hormone secretion IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II NAS
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0046884 follicle-stimulating hormone secretion IEA
 biological_processGO:0048589 developmental growth IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Mineralocorticoid biosynthesis
Glycoprotein hormones
Thyroxine biosynthesis
Hormone ligand-binding receptors
G alpha (s) signalling events
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000124302 CHST8 / Q9H2A9 / carbohydrate sulfotransferase 8  / reaction
 ENSG00000170820 FSHR / P23945 / follicle stimulating hormone receptor  / complex / reaction
 ENSG00000165409 TSHR / P16473 / thyroid stimulating hormone receptor  / complex / reaction
 ENSG00000138039 LHCGR / P22888 / luteinizing hormone/choriogonadotropin receptor  / complex / reaction
 ENSG00000104826 LHB / P01229 / luteinizing hormone beta polypeptide  / complex / reaction
 ENSG00000131808 FSHB / P01225 / follicle stimulating hormone beta subunit  / complex / reaction
 ENSG00000134200 TSHB / P01222 / thyroid stimulating hormone beta  / reaction / complex
 ENSG00000104827 CGB3 / P0DN86 / chorionic gonadotropin beta subunit 3  / complex / reaction






 

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