ENSG00000135473


Homo sapiens

Features
Gene ID: ENSG00000135473
  
Biological name :PAN2
  
Synonyms : PAN2 / PAN2 poly(A) specific ribonuclease subunit / Q504Q3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 56316223
Gene end: 56334053
  
Corresponding Affymetrix probe sets: 203117_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481859
Ensembl peptide - ENSP00000449092
Ensembl peptide - ENSP00000449861
Ensembl peptide - ENSP00000257931
Ensembl peptide - ENSP00000388231
Ensembl peptide - ENSP00000401721
NCBI entrez gene - 9924     See in Manteia.
OMIM - 617447
RefSeq - NM_001166279
RefSeq - NM_001127460
RefSeq - NM_014871
RefSeq Peptide - NP_001159751
RefSeq Peptide - NP_001120932
RefSeq Peptide - NP_055686
swissprot - Q504Q3
swissprot - F8VXK8
Ensembl - ENSG00000135473
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pan2ENSDARG00000074675Danio rerio
 PAN2ENSGALG00000031512Gallus gallus
 Pan2ENSMUSG00000005682Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR028881  PAN2 domain
 IPR028889  Ubiquitin specific protease domain
 IPR030843  PAN2-PAN3 deadenylation complex catalytic subunit PAN2
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IBA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031251 PAN complex IDA
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152520 PAN3 / Q58A45 / PAN3 poly(A) specific ribonuclease subunit  / complex






 

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