ENSMUSG00000005682


Mus musculus

Features
Gene ID: ENSMUSG00000005682
  
Biological name :Pan2
  
Synonyms : Pan2 / PAN2-PAN3 deadenylation complex catalytic subunit Pan2 / Q8BGF7
  
Possible biological names infered from orthology : PAN2 poly(A) specific ribonuclease subunit / Q504Q3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128303335
Gene end: 128321358
  
Corresponding Affymetrix probe sets: 10367252 (MoGene1.0st)   1426700_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005825
Ensembl peptide - ENSMUSP00000151216
Ensembl peptide - ENSMUSP00000151874
NCBI entrez gene - 103135     See in Manteia.
MGI - MGI:1918984
RefSeq - XM_017313756
RefSeq - NM_001252326
RefSeq - NM_001252327
RefSeq - NM_133992
RefSeq - XM_006512987
RefSeq - XM_006512988
RefSeq - XM_006512989
RefSeq - XM_006512990
RefSeq - XM_006512985
RefSeq - XM_006512986
RefSeq Peptide - NP_001239256
RefSeq Peptide - NP_598753
RefSeq Peptide - NP_001239255
swissprot - Q8BGF7
Ensembl - ENSMUSG00000005682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pan2ENSDARG00000074675Danio rerio
 PAN2ENSGALG00000031512Gallus gallus
 PAN2ENSG00000135473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012337  Ribonuclease H-like superfamily
 IPR013520  Exonuclease, RNase T/DNA polymerase III
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR028881  PAN2 domain
 IPR028889  Ubiquitin specific protease domain
 IPR030843  PAN2-PAN3 deadenylation complex catalytic subunit PAN2
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening IBA
 biological_processGO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0031251 PAN complex ISO
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1m1Anu/Rag1m1Anu
Genetic Background: C57BL/6NCrlAnu-Rag1m1Anu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029647 Pan3 / Q640Q5 / PAN2-PAN3 deadenylation complex subunit Pan3 / Q58A45* / PAN3 poly(A) specific ribonuclease subunit*  / complex






 

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