ENSG00000136381


Homo sapiens

Features
Gene ID: ENSG00000136381
  
Biological name :IREB2
  
Synonyms : IREB2 / iron responsive element binding protein 2 / P48200
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q25.1
Gene start: 78437431
Gene end: 78501456
  
Corresponding Affymetrix probe sets: 1555476_at (Human Genome U133 Plus 2.0 Array)   214666_x_at (Human Genome U133 Plus 2.0 Array)   225892_at (Human Genome U133 Plus 2.0 Array)   242261_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453863
Ensembl peptide - ENSP00000453172
Ensembl peptide - ENSP00000453058
Ensembl peptide - ENSP00000452938
Ensembl peptide - ENSP00000258886
Ensembl peptide - ENSP00000453532
Ensembl peptide - ENSP00000454063
NCBI entrez gene - 3658     See in Manteia.
OMIM - 147582
RefSeq - NM_001354994
RefSeq - NM_001320941
RefSeq - NM_001320942
RefSeq - NM_001320943
RefSeq - NM_004136
RefSeq Peptide - NP_001307870
RefSeq Peptide - NP_004127
RefSeq Peptide - NP_001341923
RefSeq Peptide - NP_001307872
RefSeq Peptide - NP_001307871
swissprot - P48200
swissprot - A0A0A6YY96
swissprot - H0YL48
swissprot - H0YLE0
swissprot - H0YMA8
swissprot - H0YN46
swissprot - H0YNL8
Ensembl - ENSG00000136381
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ireb2ENSDARG00000021466Danio rerio
 IREB2ENSGALG00000035462Gallus gallus
 Ireb2ENSMUSG00000032293Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACO1 / P21399 / aconitase 1ENSG0000012272956


Protein motifs (from Interpro)
Interpro ID Name
 IPR000573  Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
 IPR001030  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
 IPR006249  Aconitase/Iron-responsive element-binding protein 2
 IPR015928  Aconitase/3-isopropylmalate dehydratase, swivel
 IPR015931  Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
 IPR015932  Aconitase, domain 2
 IPR018136  Aconitase family, 4Fe-4S cluster binding site
 IPR029755  Iron regulatory protein 2
 IPR036008  Aconitase, iron-sulfur domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006782 protoporphyrinogen IX biosynthetic process IEA
 biological_processGO:0006826 iron ion transport TAS
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0034101 erythrocyte homeostasis IEA
 biological_processGO:0050892 intestinal absorption IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030350 iron-responsive element binding IEA
 molecular_functionGO:0030371 translation repressor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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